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Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

JOR Spine(2024)10.1002/jsp2.1303Source: DataRank Database

Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation is a research paper published in JOR Spine (2024). On theSindex it has a DataRank of 0. It has been cited 22 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access22 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 6.77)OA: goldTopics (28)IDs (PubMed, PMC, OpenAlex)SDGs (3)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

William Buchser ORCID,Zhongying Zhang ORCID,Prashanta Silwal ORCID,Michael T. Lotze ORCID,James D. Kang ORCID

Live enrichment

PubMed:38222800 PMC:PMC10782056 OpenAlex:https://openalex.org/W4390542973

National Institutes of Health

Grant: R01 AG044376‐01

Uehara Memorial Foundation

Grant: 2012400067

NIA NIH HHS

Grant: R01 AG044376

National Institutes of Health

Grant: 5R01AG044376-02

The role of cellular senescence in intervertebral disc aging

Pittsburgh Foundation

FWCI

6.77

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jsp2.1303

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jsp2.1303

publisherhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/jsp2.1303

publisherhttps://onlinelibrary.wiley.com/doi/full-xml/10.1002/jsp2.1303

journalhttps://doi.org/10.1002/jsp2.1303

Fields of Study

Spine and Intervertebral Disc PathologySpondyloarthritis Studies and TreatmentsSpinal Hematomas and Complications0301 basic medicine03 medical and health sciences

Keywords

AutophagymTORC1PI3K/AKT/mTOR pathwayCell biologyProtein kinase BMechanistic target of rapamycinmTORC2P70-S6 Kinase 1ChemistryRPTORSignal transductionBiologyApoptosisBiochemistrySpineInflammationIntervertebral discRapamycinDisc DegenerationPi3k/akt/mtor Signaling PathwayOrthopedic surgeryRD701-811Research Articles

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-beingSDG 0: No poverty