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The disordered negatively charged C‐terminus of the large HECT E3 ubiquitin ligase HERC2 provides structural and thermal stability to the HECTC‐lobe

Protein Science(2024)10.1002/pro.5229Source: DataRank Database

The disordered negatively charged C‐terminus of the large HECT E3 ubiquitin ligase HERC2 provides structural and thermal stability to the HECTC‐lobe is a research paper published in Protein Science (2024). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Enrichment:Funding (2 grants)Impact (FWCI 0.17)OA: hybridTopics (43)IDs (PubMed, PMC, OpenAlex)Annotations (1)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Kayla Rich,Noah Schwaegerle,Tianyi Yang ORCID,Shuanghong Huo ORCID,Donald E. Spratt ORCID

Live enrichment

PubMed:39565083 PMC:PMC11577452 OpenAlex:https://openalex.org/W4404536803

National Institute of General Medical Sciences

Grant: R15GM126432

National Institutes of Health

Grant: 2R15GM126432-02

Structure and Mechanism of HERC5-dependent ISGylation

FWCI

0.17

Citation Percentile

0.5%

Citation Trend

2025

hybridLicense: cc-by

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.5229

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.5229

publisherhttps://onlinelibrary.wiley.com/doi/pdf/10.1002/pro.5229

journalhttps://doi.org/10.1002/pro.5229

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39565083

Fields of Study

Ubiquitin and proteasome pathwaysDNA Repair MechanismsCancer-related Molecular Pathways0301 basic medicine0303 health sciences03 medical and health sciencesUbiquitin-Protein LigasesHumansProtein DomainsGuanine Nucleotide Exchange FactorsMolecular Dynamics SimulationProtein StabilityModels, Molecular

MeSH Terms

Protein DomainsHumansModels, MolecularGuanine Nucleotide Exchange FactorsUbiquitin-Protein LigasesProtein StabilityMolecular Dynamics Simulation

Keywords

Ubiquitin ligaseBiophysicsUbiquitinBiologyCell biologyBiochemistryGeneCircular dichroismNmr SpectroscopyDna Damage ResponseHerc2Protein RecruitmentAlphafoldDisordered TailHect E3 Ubiquitin LigaseModels, MolecularProtein DomainsProtein StabilityUbiquitin-Protein LigasesHumansGuanine Nucleotide Exchange FactorsMolecular Dynamics SimulationResearch Article

The disordered negatively charged C‐terminus of the large HECT E3 ubiquitin ligase HERC2 provides structural and thermal stability to the HECTC‐lobe

FAIR Checklist

Authors (6)

Funding (2 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)