Studies on phospholipid biosynthesis in hepatocytes from alcoholic rats by using radiolabeled exogenous precursors is a research paper published in Lipids (1996). On theSindex it has a DataRank of 0.818. It has been cited 18 times, with 8 citing works in its 1-hop citation network.
AbstractWe have studied the synthesis of phospholipids in hepatocytes isolated from chronically ethanol‐treated rats by using isotopically labelled serine, ethanolamine, and choline as exogenous precursors. Our results demonstrate that ethanol induces specific effects on the biosynthesis of phosphatidyl‐ethanolamine and phosphatidylcholinevia CDP‐derivatives and also on the synthesis of phosphatidylserinevia the Ca++‐dependent base‐exchange reaction. Thus, the synthesis of phosphatidylethanolamine from [3‐H]ethanolamine and the incorporation of [3H]serine into phosphatidylserine were clearly higher in hepatocytes from ethanol‐treated rats compared to controls. The synthesis of phosphatidylcholine from [methyl‐14C] choline, on the other hand, decreased markedly, suggesting a specific inhibition of cholinephosphotransferase activity. We have also demonstrated that the phosphatidylcholine levels are markedly decreased in hepatocytes isolated from chronically ethanol‐treated rats as a consequence of the lower phosphatidylcholine biosynthesis. The decrease in the incorporation of radioactivity from choline to betaine, which we also found, is interpreted as being the result of a higher use of betaine as methyl donor instead of methionine to maintain the hepaticS‐adenosylmethionine levels in chronic alcoholism.
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Base Score Contribution
0.442
From this paper's citation signal
Citation Network Contribution
0.377
From 6 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 54% comes from its base citations and 46% from the citation network (6 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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