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Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype

Cellular and Molecular Life Sciences(2025)10.1007/s00018-025-05913-4Source: DataRank Database

Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype is a research paper published in Cellular and Molecular Life Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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geo refseq

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (11 grants)Impact (FWCI 0.42)OA: goldTopics (42)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (19)

Kamin Kahrizi,Rosalyn W. Sayaman ORCID,Carolina DiBenedetto,Pedro J Salaberry,Roxana Pirker

Live enrichment

PubMed:41231242 PMC:PMC12615902 OpenAlex:https://openalex.org/W4416158734

NIH/NCI

Grant: 5K22CA163969

NIH/NCI

Grant: T32CA221709]

NIH/NCI

Grant: K01CA279498

NCI NIH HHS

Grant: K22 CA163969

NCI NIH HHS

Grant: T32 CA221709

Resource Allocation Program, UCSF

University of Buenos Aires

Agencia Nacional de Promocion de Ciencia y Tecnologia

Breast Research Development Program

Pink Pumpkin Patch

Swim Across America

FWCI

0.42

Citation Percentile

0.6%

Citation Trend

2025

goldLicense: cc-by

journalhttps://link.springer.com/content/pdf/10.1007/s00018-025-05913-4.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s00018-025-05913-4.pdf

publisherhttps://link.springer.com/article/10.1007/s00018-025-05913-4/fulltext.html

journalhttps://doi.org/10.1007/s00018-025-05913-4

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41231242

Fields of Study

Kruppel-like factors researchMelanoma and MAPK PathwaysWnt/β-catenin signaling in development and cancerHumansBreast NeoplasmsFemaleTranscription FactorsCell Line, TumorGene Expression Regulation, NeoplasticEpithelial-Mesenchymal TransitionCD4-Positive T-LymphocytesDNA-Binding ProteinsEnhancer Elements, GeneticPhenotypeCell LineageCell Movement

MeSH Terms

Breast NeoplasmsCell MovementDNA-Binding ProteinsEnhancer Elements, GeneticFemaleHumansPhenotypeTranscription FactorsCD4-Positive T-LymphocytesGene Expression Regulation, NeoplasticCell LineageCell Line, TumorEpithelial-Mesenchymal Transition

Keywords

Breast cancerTranscription factorPhenotypeRegulatorMaster regulatorReprogrammingCancer cellCancerRegulation of gene expressionExtracellular matrixPlasticityGene Regulatory NetworksTranscriptional Repressors

Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype

FAIR Checklist

Authors (19)

Funding (11 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)