🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

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Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice

Journal of Molecular Medicine(2020)10.1007/s00109-020-01926-7Source: DataRank Database

Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice is a research paper published in Journal of Molecular Medicine (2020). On theSindex it has a DataRank of 0. It has been cited 57 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access57 citations

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (29 grants)Impact (FWCI 2.42)OA: greenTopics (102)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Rui Yan ORCID,Stephanie Q. Pan,Raymond Wu ORCID,Jihoon Kim ORCID,Yibu Chen ORCID

Live enrichment

PubMed:32556367 PMC:PMC7810220 OpenAlex:https://openalex.org/W3036708564

National Institute on Alcohol Abuse and Alcoholism

Grant: P50AA011999

National Institute on Alcohol Abuse and Alcoholism

Grant: R21 AA023574

National Institute on Alcohol Abuse and Alcoholism

Grant: R01 AA022489

National Institute on Alcohol Abuse and Alcoholism

Grant: R24AA012885

National Institute on Alcohol Abuse and Alcoholism

Grant: R01AA018663

National Institute on Alcohol Abuse and Alcoholism

Grant: U01AA027681

Japan Society for the Promotion of Science

Grant: JP16H06872

Japan Society for the Promotion of Science

Grant: JP17K09419

National Institutes of Health

Grant: U54HL108460

National Institutes of Health

Grant: P41 GM103493

National Institutes of Health

Grant: DK082451

VA

Grant: I01BX001991

VA

Grant: IK6BX004205

NIDDK NIH HHS

Grant: R01 DK082451

NIH HHS

Grant: S10 OD023527

NIAAA NIH HHS

Grant: U01 AA018663

NIAAA NIH HHS

Grant: R01 AA028134

NIAAA NIH HHS

Grant: U01 AA022489

National Institutes of Health

Grant: 5IK6BX004205-06

BLR&D Research Career Scientist Award Application

National Institutes of Health

Grant: 1R21AA023574-01A1

Encapsulated RNAs in extracellular vesicles contribute ALD progression

National Institutes of Health

Grant: 5I01BX001991-10

Molecular Mechanisms of Stellate Cell Activation in Liver Fibrosis

National Institutes of Health

Grant: 1U54HL108460-01

Core 3

National Institutes of Health

Grant: 8P41GM103493-10

A Proteomics Research Resource for Integrative Biology

National Institutes of Health

Grant: 3P50AA011999-12S1

Southern California Research Center for ALPD and Cirrhosis

National Institutes of Health

Grant: 1S10OD023527-01

JEOL JEM-1400Plus Transmission Electron Microscope

National Institutes of Health

Grant: 1U01AA027681-01

Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors

National Institutes of Health

Grant: 5R01DK082451-02

Caspase Dependent Cell Death in Nonalcoholic Fatty Liver Disease

National Institutes of Health

Grant: 5R24AA012885-25

Integrative Liver Cell Core

National Institutes of Health

Grant: 1U01AA022489-01A1

Oxidized Metabolites of Linoleic Acid in Alcohol-induced Liver Injury

FWCI

2.42

Citation Percentile

0.9%

Citation Trend

2012

2020

2021

2022

2023

2024

2025

2026

greenLicense: Springer TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7810220

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7810220

publisherhttps://link.springer.com/content/pdf/10.1007/s00109-020-01926-7.pdf

publisherhttps://link.springer.com/article/10.1007/s00109-020-01926-7/fulltext.html

journalhttps://doi.org/10.1007/s00109-020-01926-7

Fields of Study

Extracellular vesicles in diseaseLiver Disease and TransplantationLiver Disease Diagnosis and Treatment0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsDNA, MitochondrialDown-RegulationExtracellular VesiclesHepatic Stellate CellsHepatitis, AlcoholicHepatocytesHumansInterleukin-17Interleukin-1betaLiverMacrophagesMaleMiceMice, Inbred C57BLMicroRNAsUp-Regulation

MeSH Terms

Extracellular VesiclesAnimalsDNA, MitochondrialHepatitis, AlcoholicHumansLiverMacrophagesMaleMice, Inbred C57BLDown-RegulationUp-RegulationInterleukin-17HepatocytesMicroRNAsMiceInterleukin-1betaHepatic Stellate Cells

Keywords

Hepatic stellate cellDownregulation and upregulationExtracellular vesiclesHepatocytemicroRNACell biologyDampChemistryExtracellularAlcoholic hepatitisBiologyCirrhosisAlcoholic liver diseaseMedicineBiochemistryGenePathologyIn vitroGastroenterologymiRNAsDampsAhHsc ActivationHepatocyte-derived EvsHepatic Macrophage ActivationMaleChronic Liver Disease and CirrhosisImmunologyInterleukin-1betaDown-RegulationInbred C57BLDNA, MitochondrialOral and gastrointestinalHepatitisMedicinal and Biomolecular ChemistrySubstance MisuseAlcohol Use and HealthMiceGeneticsHepatic Stellate Cells2.1 Biological and endogenous factorsAnimalsHumansAetiologyHepatitis, AlcoholicPreventionLiver DiseaseMacrophagesInterleukin-17DNAAlcoholicMitochondrialUp-RegulationMice, Inbred C57BLAlcoholismMicroRNAsGood Health and Well BeingLiverChemical SciencesHepatocytesDigestive DiseasesBiotechnology

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being