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Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight

Journal of Molecular Medicine(2022)10.1007/s00109-021-02165-0Source: DataRank Database

Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight is a research paper published in Journal of Molecular Medicine (2022). On theSindex it has a DataRank of 0.243. It has been cited 3 times, with 3 citing works in its 1-hop citation network.

N/A

0.243DataRank · unranked

Scored on demand from live citation data

Open Access3 citations · 3 citing works in its network

Cite:

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (20 grants)Impact (FWCI 0.56)OA: hybridTopics (50)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 86%Citation Network 14%

Base Score Contribution

0.208

From this paper's citation signal

Citation Network Contribution

0.0347

From 2 citing papers with measurable signal

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Top 3 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 3 citers.

Causal effect of polyunsaturated fatty acids on bone mineral density and fracture
Frontiers in Nutrition20227 citations83 referencesContributes 0.025
B lymphocytes impair osteogenesis by inhibiting BMSC differentiation in osteoporosis
Immunobiology20251 citations44 referencesContributes 0.016
Severe liver damage, low bone mineral content, and PDXDC1/TTC39B gene variations linked to NAFLD with metabolic syndrome
medRxiv20230 citations50 referencesContributes 0.000

Authors (16)

Shidi Hu,Lin Xu ORCID,Xiang‐He Meng ORCID,Xiao Wang ORCID,Yinhua Zhang ORCID

Live enrichment

PubMed:35314877 OpenAlex:https://openalex.org/W4220998288

foundation for the national institutes of health

Grant: R01AR057049

foundation for the national institutes of health

Grant: R01AR059781

foundation for the national institutes of health

Grant: R01MH107354

foundation for the national institutes of health

Grant: R01MH104680

foundation for the national institutes of health

Grant: R01GM109068

foundation for the national institutes of health

Grant: U19AG055373

foundation for the national institutes of health

Grant: R01AR069055

the science and technology program of guangzhou

Grant: 201604020007

national natural science foundation of china

Grant: 81770878

national natural science foundation of china

Grant: 81800794

the phd start-up fund of natural science foundation of guangdong province

Grant: 2017A030310390

medical science and technology foundation of guangdong province

Grant: A2019005

guangzhou planed project of science and technology

Grant: 201903010091

National Institutes of Health

Grant: 5U19AG055373-04

Trans-omics integration of multi-omics studies for male osteoporosis

National Institutes of Health

Grant: 5R01GM109068-04

Integration of multiscale genomic data for comprehensive analysis of complex dise

National Institutes of Health

Grant: 5R01MH104680-03

Integration of brain imaging with genomic and epigenomic data

National Institutes of Health

Grant: 1R01AR069055-01A1

Decoding Methylation Mediated Epigenomic Contributions to Male Osteoporosis

National Institutes of Health

Grant: 5R01AR057049-06

Identification of Proteins Important for Male Osteoporosis

National Institutes of Health

Grant: 5R01MH107354-03

Integration of fMRI imaging, genomics, network and biological knowledge

National Institutes of Health

Grant: 5R01AR059781-02

Epigenomewide DNA Methylation Study for Osteoporosis Risk

FWCI

0.56

Citation Percentile

0.6%

Citation Trend

2022

2023

2025

hybridLicense: cc-by

journalhttps://link.springer.com/content/pdf/10.1007/s00109-021-02165-0.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s00109-021-02165-0.pdf

publisherhttps://link.springer.com/article/10.1007/s00109-021-02165-0/fulltext.html

journalhttps://doi.org/10.1007/s00109-021-02165-0

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35314877

Fields of Study

Bone health and osteoporosis researchFolate and B Vitamins ResearchBirth, Development, and Health0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsMiceBirth WeightBone DensityCalcium Channels, T-TypeCarboxy-LyasesGenetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single Nucleotide

MeSH Terms

AnimalsBirth WeightCarboxy-LyasesBone DensityGenetic Predisposition to DiseasePolymorphism, Single NucleotideCalcium Channels, T-TypeMiceGenome-Wide Association Study

Keywords

Genome-wide association studyBone mineralOsteoporosisBiologyPleiotropyPhenotypeCandidate geneGeneticsLocus (genetics)EndocrinologySingle-nucleotide polymorphismGeneInternal medicineMedicineGenotypeMiceCalcium Channels, T-TypeBone DensityCarboxy-LyasesAnimalsBirth WeightOriginal ArticleGenetic Predisposition to DiseasePolymorphism, Single NucleotideBone mineral densityConditional false discovery rate

Sustainable Development Goals

SDG 0: Good health and well-being