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Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging

Archives of Toxicology(2025)10.1007/s00204-025-03985-6Source: DataRank Database

Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging is a research paper published in Archives of Toxicology (2025). On theSindex it has a DataRank of 0. It has been cited 10 times.

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Open Access10 citations

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Enrichment:Funding (4 grants)Impact (FWCI 8.71)OA: hybridTopics (49)IDs (PubMed, PMC, OpenAlex)Annotations (2)

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Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Nikolina Maček Hrvat ORCID,Goran Šinko ORCID,Jarosław Kalisiak ORCID,Zoran Radić ORCID,Valery V. Fokin ORCID

Live enrichment

PubMed:40032685 PMC:PMC12085358 OpenAlex:https://openalex.org/W4408101634

Hrvatska Zaklada za Znanost

Grant: IP-2022-10-6685

Analyses of interactions between organophosphorus compounds and esterases and other targets for therapy in poisoning

Hrvatska Zaklada za Znanost

Grant: IP-2018-01-7683

Analysis of butyrylcholinesterase interactions with novel inhibitors and reactivators

NINDS NIH HHS

Grant: U01 NS058046

National Institutes of Health

Grant: 3U01NS058046-05S1

Oxime-Assisted Catalysis of Organophosphates and Reactivation of AChE

FWCI

8.71

Citation Percentile

1.0%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1007/s00204-025-03985-6

publisherhttps://doi.org/10.1007/s00204-025-03985-6

publisherhttps://link.springer.com/content/pdf/10.1007/s00204-025-03985-6.pdf

publisherhttps://link.springer.com/article/10.1007/s00204-025-03985-6/fulltext.html

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40032685

Fields of Study

Pesticide Exposure and ToxicityCholinesterase and Neurodegenerative DiseasesInsect and Pesticide Research

MeSH Terms

Nerve AgentsAnimalsButyrylcholinesteraseChemical Warfare AgentsCholinesterase InhibitorsCholinesterase ReactivatorsHumansKineticsModels, MolecularOrganophosphorus CompoundsOrganothiophosphorus CompoundsOximesOrganophosphatesSarinClick Chemistry

Keywords

Nerve agentChemistryButyrylcholinesteraseOximeSarinTabunAcetylcholinesterasePyridiniumStereochemistryCombinatorial chemistryMedicinal chemistryBiochemistryEnzymeAchéOrganophosphorus compoundsAntidotes2-PamObidoximeModels, MolecularCholinesterase ReactivatorsOrganothiophosphorus CompoundsOrganophosphatesOrgan Toxicity and MechanismsKineticsOximesHumansAnimalsClick ChemistryCholinesterase InhibitorsChemical Warfare AgentsNerve Agents

Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging

FAIR Checklist

Authors (9)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)