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Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells

Cancer Immunology Immunotherapy(2022)10.1007/s00262-021-03126-9Source: DataRank Database

Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells is a research paper published in Cancer Immunology Immunotherapy (2022). On theSindex it has a DataRank of 0. It has been cited 34 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access34 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)Impact (FWCI 2.34)OA: hybridTopics (59)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Carina Magdaleno,Emyly Fernandez,Trenton House ORCID,Srividya Swaminathan ORCID,Archana Varadaraj ORCID

Live enrichment

PubMed:34999917 PMC:PMC9294031 OpenAlex:https://openalex.org/W4205446865

national institutes of health

Grant: U54MD012388

national cancer institute

Grant: U54CA143925

National Institutes of Health

Grant: 5U54CA143925-08

The Partnership for Native American Cancer Prevention (1 OF 2)

National Institutes of Health

Grant: 3U54MD012388-04S6

Southwest Health Equity Research Collaborative

FWCI

2.34

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://link.springer.com/content/pdf/10.1007/s00262-021-03126-9.pdf

HYBRIDhttps://link.springer.com/content/pdf/10.1007/s00262-021-03126-9.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s00262-021-03126-9.pdf

publisherhttps://link.springer.com/article/10.1007/s00262-021-03126-9/fulltext.html

journalhttps://doi.org/10.1007/s00262-021-03126-9

Fields of Study

Immune Cell Function and InteractionCancer, Hypoxia, and MetabolismImmune cells in cancerMedicineBiology0301 basic medicine03 medical and health sciences0302 clinical medicineCell HypoxiaCell Line, TumorHumansHypoxia-Inducible Factor 1, alpha SubunitInterleukin-2Killer Cells, NaturalNeoplasmsPhosphatidylinositol 3-KinasesSignal TransductionTOR Serine-Threonine Kinases

MeSH Terms

HumansInterleukin-2Killer Cells, NaturalNeoplasmsSignal TransductionCell HypoxiaPhosphatidylinositol 3-KinasesCell Line, TumorHypoxia-Inducible Factor 1, alpha SubunitTOR Serine-Threonine Kinases

Keywords

Cytotoxic T cellBiologyCell biologyPI3K/AKT/mTOR pathwayInterleukin 12EffectorLymphokine-activated killer cellInterleukin 21Natural killer cellCancer researchEx vivoImmune systemImmunologyT cellIn vivoSignal transductionIn vitroHypoxiaIL-2Natural killer cellsHIF-1αTOR Serine-Threonine KinasesHypoxia-Inducible Factor 1, alpha SubunitCell HypoxiaKiller Cells, NaturalPhosphatidylinositol 3-KinasesCell Line, TumorNeoplasmsHumansInterleukin-2Original Article

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells

FAIR Checklist

Authors (7)

Funding (4 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)