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Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors

Basic Research in Cardiology(2021)10.1007/s00395-021-00900-9Source: DataRank Database

Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors is a research paper published in Basic Research in Cardiology (2021). On theSindex it has a DataRank of 0.677. It has been cited 90 times.

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0.677DataRank · unranked

Scored on demand from live citation data

Open Access90 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 7.74)OA: hybridTopics (109)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.677

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (8)

Risto-Pekka Pölönen ORCID,Kim T. Hellgren ORCID,Christopher Y. Ko ORCID,Kenneth S. Ginsburg,Julie Bossuyt ORCID

Live enrichment

PubMed:34648073 PMC:PMC8516771 OpenAlex:https://openalex.org/W3207515186

national institutes of health

Grant: P01-141084

national institutes of health

Grant: R01-142282

suomen kulttuurirahasto

Grant: 00200088

NHLBI NIH HHS

Grant: R01 HL142282

NHLBI NIH HHS

Grant: P01 HL141084

NHLBI NIH HHS

Grant: R01 HL130840

NHLBI NIH HHS

Grant: R01 HL092097

NHLBI NIH HHS

Grant: R01 HL138539

National Institutes of Health

Grant: 5P01HL141084-04

Elucidating Electro-Mechanical Dysfunction in Heart Failure with Human Stem Cell Models

osk. huttusen säätiö

FWCI

7.74

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://link.springer.com/content/pdf/10.1007/s00395-021-00900-9.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s00395-021-00900-9.pdf

publisherhttps://link.springer.com/article/10.1007/s00395-021-00900-9/fulltext.html

journalhttps://doi.org/10.1007/s00395-021-00900-9

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34648073

Fields of Study

Cardiac electrophysiology and arrhythmiasIon channel regulation and functionNeuroscience and Neural Engineering0301 basic medicine0303 health sciences03 medical and health sciencesAction PotentialsAnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2FemaleHumansInduced Pluripotent Stem CellsMyocytes, CardiacPregnancyRabbitsReactive Oxygen SpeciesRyanodine Receptor Calcium Release Channel

MeSH Terms

Action PotentialsAnimalsCalciumFemaleHumansPregnancyRabbitsReactive Oxygen SpeciesRyanodine Receptor Calcium Release ChannelMyocytes, CardiacCalcium-Calmodulin-Dependent Protein Kinase Type 2Induced Pluripotent Stem Cells

Keywords

Ryanodine receptorAfterdepolarizationDantroleneSERCARyanodine receptor 2Internal medicineMitochondrial ROSChemistryEndocrinologyCatecholaminergic polymorphic ventricular tachycardiaPharmacologyMedicineReceptorCalciumOxidative stressATPaseRepolarizationBiochemistryElectrophysiologyROSCaMKIIHeart FailureRyrMedical PhysiologyAction Potentials (mesh)Stem Cell Research - Induced Pluripotent Stem Cell - Human (rcdc)Action PotentialsCardiorespiratory Medicine and Haematology3208 Medical Physiology (for-2020)CardiovascularPregnancyAnimals (mesh)Myocytes, Cardiac32 Biomedical and Clinical Sciences (for-2020)PediatricHumans (mesh)Stem Cell Research - Induced Pluripotent Stem Cell - HumanCongenital Heart Disease (rcdc)Congenital Heart Disease3201 Cardiovascular medicine and haematology (for-2020)Original ContributionInduced Pluripotent Stem Cells (mesh)Heart Disease5.1 PharmaceuticalsCardiovascular (rcdc)FemaleRabbitsCardiacStem Cell Research - Induced Pluripotent Stem Cell (rcdc)Induced Pluripotent Stem CellsHeart Disease (rcdc)610Cardiovascular medicine and haematologyRare Diseases (rcdc)Rare Diseases5.1 Pharmaceuticals (hrcs-rac)Calcium (mesh)Rabbits (mesh)1102 Cardiorespiratory Medicine and Haematology (for)AnimalsHumansCardiovascular System & Hematology (science-metrix)Pediatric (rcdc)Calcium-Calmodulin-Dependent Protein Kinase Type 2 (mesh)MyocytesCardiovascular (hrcs-hc)Biomedical and Clinical SciencesStem Cell Research - Induced Pluripotent Stem CellReactive Oxygen Species (mesh)Ryanodine Receptor Calcium Release ChannelStem Cell ResearchStem Cell Research (rcdc)Cardiac (mesh)Ryanodine Receptor Calcium Release Channel (mesh)Pregnancy (mesh)Cardiovascular System & HematologyFemale (mesh)Calcium-Calmodulin-Dependent Protein Kinase Type 2Reactive Oxygen Species

Sustainable Development Goals

SDG 3: 3. Good health

Additional file 1 of Exosomes secreted by endothelial cells derived from human induced pluripotent stem cells improve recovery from myocardial infarction in mice

10.6084/m9.figshare.24223802.v1figshare

Additional file 1 of Exosomes secreted by endothelial cells derived from human induced pluripotent stem cells improve recovery from myocardial infarction in mice

10.6084/m9.figshare.24223802figshare