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Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions

Acta Neuropathologica(2021)10.1007/s00401-021-02399-9Source: DataRank Database

Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions is a research paper published in Acta Neuropathologica (2021). On theSindex it has a DataRank of 0. It has been cited 44 times.

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Open Access44 citations

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Enrichment:Funding (21 grants)OA: greenTopics (26)IDs (PubMed, PMC)Annotations (3)SDGs (1)

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Authors (7)

Jack Humphrey ORCID,Conceição Bettencourt ORCID,Jia Newcombe ORCID,Tammaryn Lashley ORCID,Pietro Fratta ORCID

Live enrichment

PubMed:34961893 PMC:PMC10725322

National Institute on Aging

Grant: R56-AG055824

National Institute on Aging

Grant: U01-AG068880

Medical Research Council

Grant: MR/M008606/1

Investigating deficits of axonal RNA metabolism and axonal signalling in amyotrophic lateral sclerosis

Medical Research Council

Grant: MR/S006508/1

The impact of TDP-43 on translation and the response to axonal damage in amyotrophic lateral sclerosis

Alzheimer’s Research UK

Grant: ARUK-RF2019B-005

Motor Neurone Disease Association

Grant: FRATTA/JAN15/946-795

Rosetrees

Grant: M599

NIA NIH HHS

Grant: R56 AG055824

Motor Neurone Disease Association

Grant: Fratta/Apr19/868-791

Medical Research Council

Grant: MC_PC_MR/S022708/1

Motor Neurone Disease Association

Grant: Fratta/Apr19/893-792

NIH HHS

Grant: S10 OD018522

NIH HHS

Grant: S10 OD026880

Motor Neurone Disease Association

Grant: Fratta/Mar19/951-795

NIA NIH HHS

Grant: P30 AG066514

NIA NIH HHS

Grant: U01 AG068880

National Institutes of Health

Grant: 3U01AG068880-02S1

Learning the Regulatory Code of Alzheimer's Disease Genomes

National Institutes of Health

Grant: 1S10OD018522-01

Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC Supercomputer

National Institutes of Health

Grant: 1R56AG055824-01A1

The Role of Alternative Splicing in Neurodegeneration

National Institutes of Health

Grant: 1S10OD026880-01

Big Omics Data Engine 2 Supercomputer

National Institute for Health Research (NIHR)

greenLicense: Springer TDM

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10725322/pdf/nihms-1944184.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s00401-021-02399-9.pdf

publisherhttps://link.springer.com/article/10.1007/s00401-021-02399-9/fulltext.html

https://doi.org/10.1007/s00401-021-02399-9

https://doi.org/10.1101/2021.10.06.21264635

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences0302 clinical medicine

MeSH Terms

BrainEndothelial CellsHumansDNA-Binding ProteinsFrontotemporal Lobar DegenerationFrontotemporal DementiaTranscriptome

Keywords

DementiaGene ExpressionRna-seqTdp-43TranscriptomicsFtdFtldFtld-tdpBrainEndothelial CellsDNA-Binding ProteinsFrontotemporal DementiaHumansFrontotemporal Lobar DegenerationTranscriptome

Sustainable Development Goals

SDG 3: 3. Good health