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Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction

Acta Neuropathologica(2024)10.1007/s00401-024-02835-6Source: DataRank Database

Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction is a research paper published in Acta Neuropathologica (2024). On theSindex it has a DataRank of 0. It has been cited 28 times.

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Scored on demand from live citation data

Open Access28 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (22 grants)Impact (FWCI 12.74)OA: hybridTopics (57)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Imdadul Haq,Jason C. Ngo,David A. Bennett ORCID,Andrew F. Teich ORCID,Philip L. De Jager ORCID

Live enrichment

PubMed:39604588 PMC:PMC11602836 OpenAlex:https://openalex.org/W4404787625

National Institutes of Health

Grant: R01AG070118

NCRR NIH HHS

Grant: S10 RR027050

NIA NIH HHS

Grant: U01 AG061356

NIA NIH HHS

Grant: P30 AG010161

NIA NIH HHS

Grant: P30 AG072975

NIA NIH HHS

Grant: R01 AG015819

NIA NIH HHS

Grant: U01 AG046152

NIA NIH HHS

Grant: P30 AG066462

NIA NIH HHS

Grant: R01 AG072471

NIA NIH HHS

Grant: R01 AG017917

NIH HHS

Grant: S10 OD020056

National Institutes of Health

Grant: 1P30AG010161-01

SHORT-TERM STABILITY OF CLINICAL TESTS

National Institutes of Health

Grant: 5R01AG015819-07

Risk Factors, Pathology, and Clinical Expressions of AD

National Institutes of Health

Grant: 5R01AG017917-20

Epidemiologic Study of Neural Reserve and Neurobiology of Aging

National Institutes of Health

Grant: 4R01AG072471-02

Interrogation of a human microglia phenotype associated with Alzheimer's disease

National Institutes of Health

Grant: 1S10OD020056-01

BD Biosciences Influx

National Institutes of Health

Grant: 5P30AG072975-02

Rush Alzheimer's Disease Research Center

National Institutes of Health

Grant: 7U01AG046152-05

Pathway discovery, validation and compound identification for Alzheimer's disease

National Institutes of Health

Grant: 1S10RR027050-01A1

Becton Dickinson LSR II Analytical Flow Cytometer

National Institutes of Health

Grant: 3P30AG066462-01S1

Alzheimer's Disease Research Center Determinants of health seeking behaviors during COVID-19 in persons with MCI/ADRD and their caregivers

National Institutes of Health

Grant: 3U01AG061356-02S1

Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targets

National Institutes of Health

Grant: 1R01AG070118-01

Functional dissection of fibronectin type 3 domains of SORL1 in Alzheimers disease associated microglia

FWCI

12.74

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://link.springer.com/content/pdf/10.1007/s00401-024-02835-6.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s00401-024-02835-6.pdf

publisherhttps://link.springer.com/article/10.1007/s00401-024-02835-6/fulltext.html

journalhttps://doi.org/10.1007/s00401-024-02835-6

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39604588

Fields of Study

Chromosomal and Genetic VariationsAdvanced biosensing and bioanalysis techniquesStudies on Chitinases and Chitosanases03 medical and health sciences0302 clinical medicineHumansAlzheimer DiseaseMicrogliaLong Interspersed Nucleotide ElementsMaleAgedFemaleAged, 80 and overInduced Pluripotent Stem CellsAmyloid beta-Peptides

MeSH Terms

AgedAged, 80 and overAlzheimer DiseaseFemaleHumansMaleAmyloid beta-PeptidesMicrogliaLong Interspersed Nucleotide ElementsInduced Pluripotent Stem Cells

Keywords

MicrogliaBiologyAlzheimer's diseaseAmyloid betaDownregulation and upregulationTranscriptomePresenilinNeuroscienceGene expressionCell biologyImmunologyPathologyDiseaseMedicineInflammationGeneticsGeneTransposable elementsAlzheimer’s diseaseRetrotransposonsneuroinflammationLine-1MaleAged, 80 and overOriginal PaperLong Interspersed Nucleotide ElementsAmyloid beta-PeptidesAlzheimer DiseaseInduced Pluripotent Stem CellsHumansFemaleAged