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Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome–Alzheimer’s disease

Acta Neuropathologica(2025)10.1007/s00401-025-02889-0Source: DataRank Database

Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome–Alzheimer’s disease is a research paper published in Acta Neuropathologica (2025). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (12 grants)Impact (FWCI 9.44)OA: hybridTopics (57)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Yazead Buhidma ORCID,Paige Mumford ORCID,Wendy Heywood ORCID,Jenny Hällqvist ORCID,Lisi Flores Aguilar ORCID

Live enrichment

PubMed:40387921 PMC:PMC12089208 OpenAlex:https://openalex.org/W4410504586

Alzheimer's Society

Grant: AS-PhD-19a-007

UK Dementia Research Institute

Grant: UKDRI-1211

UK Dementia Research Institute

Grant: UKDRI-1014

National Institute on Aging

Grant: U19AG068054

Alzheimer’s Association

Grant: 23AARFD-1022715

Fondation Jérôme Lejeune

Grant: JLF-5694682

Alzheimer’s Research UK

Grant: ARUK-SRF2018A-001

Rosetrees Trust

Grant: MB2020\100003

Alzheimer's Society

Grant: 007

NCATS NIH HHS

Grant: UM1 TR004927

National Institutes of Health

Grant: 1U19AG068054-01

Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)

National Institutes of Health

Grant: 3P30AG066519-01S1

The Alzheimer's Disease Research Center at the University of California, Irvine

FWCI

9.44

Citation Percentile

1.0%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://link.springer.com/content/pdf/10.1007/s00401-025-02889-0.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s00401-025-02889-0.pdf

publisherhttps://link.springer.com/article/10.1007/s00401-025-02889-0/fulltext.html

journalhttps://doi.org/10.1007/s00401-025-02889-0

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40387921

Fields of Study

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments03 medical and health sciences0302 clinical medicine

MeSH Terms

Healthy AgingSingle-Cell Gene Expression AnalysisAdultAgedAlzheimer DiseaseApolipoproteins EBrainChromosomes, Human, Pair 21Down SyndromeFemaleHumansMaleMiddle AgedCase-Control StudiesProteomeTranscriptome

Keywords

TrisomyDown syndromeApolipoprotein EChromosome 21Context (archaeology)ProteomeDiseaseBiologyDementiaTranscriptomeAlzheimer's diseaseGeneticsChromosomeInternal medicineMedicineGene expressionGeneMass spectrometryapoENeuropathologyFrontal cortexTrisomy 21Amyloid Precursor ProteinMaleAdultOriginal PaperChromosomes, Human, Pair 21BrainMiddle AgedArticleSingle-Cell Gene Expression AnalysisHealthy AgingApolipoproteins EAlzheimer DiseaseCase-Control StudiesHumansFemale

Sustainable Development Goals

SDG 0: No poverty