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Chronic Diclofenac Exposure Increases Mitochondrial Oxidative Stress, Inflammatory Mediators, and Cardiac Dysfunction

Cardiovascular Drugs and Therapy(2021)10.1007/s10557-021-07253-4Source: DataRank Database

Chronic Diclofenac Exposure Increases Mitochondrial Oxidative Stress, Inflammatory Mediators, and Cardiac Dysfunction is a research paper published in Cardiovascular Drugs and Therapy (2021). On theSindex it has a DataRank of 0. It has been cited 36 times.

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Open Access36 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)Impact (FWCI 3.17)OA: hybridTopics (52)IDs (PubMed, OpenAlex)SDGs (3)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Lu Ren ORCID,Wilson Xu ORCID,James Overton ORCID,Valeriy Timofeyev,Carol Nader

Live enrichment

PubMed:34499283 OpenAlex:https://openalex.org/W3196370495

national institutes of health

Grant: T32 HL86350

national institutes of health

Grant: F32 HL149288

american heart association

Grant: 18PRE34030199

national institute of environmental health sciences

Grant: P42ES04699

national institute of environmental health sciences

Grant: RIVER R35 ES030443

national heart, lung, and blood institute

Grant: R01 HL085727

national heart, lung, and blood institute

Grant: R01 HL085844

national heart, lung, and blood institute

Grant: R01 HL137228

national heart, lung, and blood institute

Grant: S10 RR033106

u.s. department of veterans affairs

Grant: I01 BX000576

u.s. department of veterans affairs

Grant: I01 CX001490

american heart association career development award

Grant: 18CDA34110060

National Institutes of Health

Grant: 5F32HL149288-02

Novel Mechanisms of Cardiac pH Regulation During Ischemia/Reperfusion

National Institutes of Health

Grant: 2T32HL086350-16A1

Training Program in Basic and Translational Cardiovascular Science

National Institutes of Health

Grant: 5R01HL085844-12

Functional Interactions of Cardiac Ion Channels

National Institutes of Health

Grant: 5R35ES030443-04

Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseases

National Institutes of Health

Grant: 5P42ES004699-30

Biomarkers of Exposure to Hazardous Substances

National Institutes of Health

Grant: 5R01HL137228-03

Decoding the enigma of cardiac amplification

National Institutes of Health

Grant: 5R01HL085727-12

Translational Study of Cardiac Dysfunction

FWCI

3.17

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://link.springer.com/content/pdf/10.1007/s10557-021-07253-4.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s10557-021-07253-4.pdf

publisherhttps://link.springer.com/article/10.1007/s10557-021-07253-4/fulltext.html

journalhttps://doi.org/10.1007/s10557-021-07253-4

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34499283

Fields of Study

Inflammatory mediators and NSAID effectsEicosanoids and Hypertension PharmacologyPharmacogenetics and Drug Metabolism0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

AnimalsAnti-Inflammatory Agents, Non-SteroidalDiclofenacHeart DiseasesReactive Oxygen SpeciesOxidative StressInflammation MediatorsMyocytes, CardiacMiceCardiotoxicity

Keywords

MedicineOxidative stressInflammationCardiac dysfunctionDiclofenacMitochondrionPharmacologyInternal medicineHeart failureBiochemistryHeart DiseasesMedical PhysiologyAnti-Inflammatory Agents610CardiovascularCardiovascular medicine and haematologyMiceNonsteroidal anti-inflammatory drug2.1 Biological and endogenous factorsAnimalsMyocytes, CardiacMyocytesBiomedical and Clinical SciencesAnti-Inflammatory Agents, Non-Steroidal600Pharmacology and Pharmaceutical SciencesCardiotoxicityMitochondriaHeart DiseaseCardiovascular System & Hematology5.1 PharmaceuticalsOriginal ArticleInflammation MediatorsNon-SteroidalReactive Oxygen SpeciesCardiac

Sustainable Development Goals

SDG 3: 3. Good healthSDG 7: 7. Clean energySDG 0: Affordable and clean energy