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HIV-1 Tat Protein Exposure Alters the Morphological Characteristics and Gene Expression in the Primary Mouse Cortex Endothelial Cells and Human Brain Microvascular Endothelial Cells

Cellular and Molecular Neurobiology(2025)10.1007/s10571-025-01640-3Source: DataRank Database

HIV-1 Tat Protein Exposure Alters the Morphological Characteristics and Gene Expression in the Primary Mouse Cortex Endothelial Cells and Human Brain Microvascular Endothelial Cells is a research paper published in Cellular and Molecular Neurobiology (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (11 grants)Impact (FWCI 0.58)OA: hybridTopics (60)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Ichiro Manabe ORCID,Rieko Muramatsu ORCID,Jun Zhu ORCID,Lili Quan ORCID

Live enrichment

PubMed:41353488 PMC:PMC12796040 OpenAlex:https://openalex.org/W4417081915

Japan Society for the Promotion Science

Grant: JP23K27592

Japan Society for the Promotion Science

Grant: 23K24223

Japan Society for the Promotion Science

Grant: 22H02962

Japan Science and Technology Agency grant

Grant: JPMJMS2023

National Institutes of Health

Grant: DA035714

NIDA NIH HHS

Grant: R01 DA035714

NIDA NIH HHS

Grant: R01 DA047924

NIDA NIH HHS

Grant: R01 DA057866

National Institutes of Health

Grant: 5R01DA047924-04

Allosteric Modulators of Dopamine Transporter as Therapeutic Agents for NeuroAIDS

National Institutes of Health

Grant: 5R01DA035714-07

Molecular mechanisms: Dysregulation of monoamine transporters by HIV-1 Tat and cocaine

National Institutes of Health

Grant: 5R01DA057866-02

Effects of HIV-1 Tat protein and methamphetamine on VMAT2-mediated dopamine transmission in the context of neuroHIV and drug abuse

FWCI

0.58

Citation Percentile

0.7%

Citation Trend

2026

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1007/s10571-025-01640-3

HYBRIDhttps://doi.org/10.1007/s10571-025-01640-3

publisherhttps://doi.org/10.1007/s10571-025-01640-3

publisherhttps://link.springer.com/content/pdf/10.1007/s10571-025-01640-3.pdf

publisherhttps://link.springer.com/article/10.1007/s10571-025-01640-3

Fields of Study

HIV Research and TreatmentBarrier Structure and Function StudiesAlzheimer's disease research and treatmentsMedicineBiology0301 basic medicine03 medical and health sciencesAnimalsEndothelial Cellstat Gene Products, Human Immunodeficiency VirusHumansMiceHIV-1MicrovesselsBlood-Brain BarrierBrainCells, CulturedGene Expression RegulationMice, Inbred C57BL

MeSH Terms

AnimalsBlood-Brain BarrierBrainCells, CulturedGene Expression RegulationHumansMice, Inbred C57BLHIV-1Endothelial CellsMicetat Gene Products, Human Immunodeficiency VirusMicrovessels

Keywords

PhalloidinGene expressionDownregulation and upregulationTranscriptomeEndothelial stem cellHuman brainRegulation of gene expressionEndotheliumGene knockdownGeneHIVInflammationTatEndothelial CellBlood–brain BarrierEndothelial CellsBrainArticleMice, Inbred C57BLMiceGene Expression RegulationBlood-Brain BarrierMicrovesselsHIV-1AnimalsHumanstat Gene Products, Human Immunodeficiency VirusCells, CulturedOriginal Research

HIV-1 Tat Protein Exposure Alters the Morphological Characteristics and Gene Expression in the Primary Mouse Cortex Endothelial Cells and Human Brain Microvascular Endothelial Cells

FAIR Checklist

Authors (4)

Funding (11 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)