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Physiologically-based pharmacokinetic model for predicting drug-drug interactions perpetrated by posaconazole in healthy subjects with normal weight and obesity: Concomitant use and washout

Journal of Pharmacokinetics and Pharmacodynamics(2025)10.1007/s10928-025-09983-6Source: DataRank Database

Physiologically-based pharmacokinetic model for predicting drug-drug interactions perpetrated by posaconazole in healthy subjects with normal weight and obesity: Concomitant use and washout is a research paper published in Journal of Pharmacokinetics and Pharmacodynamics (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)Impact (FWCI 0.87)OA: hybridTopics (74)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Ahmed Elmokadem ORCID,David J. Greenblatt ORCID,Christina R. Chow ORCID,Christopher D. Bruno

Live enrichment

PubMed:40681739 PMC:PMC12274254 OpenAlex:https://openalex.org/W4412520612

National Institutes of Health

Grant: UM1TR004398

National Institutes of Health

Grant: 5UM1TR004398-03

Tufts Clinical and Translational Science Institute

FWCI

0.87

Citation Percentile

0.7%

Citation Trend

2026

hybridLicense: cc-by-nc-nd

journalhttps://link.springer.com/content/pdf/10.1007/s10928-025-09983-6.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s10928-025-09983-6.pdf

publisherhttps://link.springer.com/article/10.1007/s10928-025-09983-6/fulltext.html

journalhttps://doi.org/10.1007/s10928-025-09983-6

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40681739

Fields of Study

Pharmacogenetics and Drug MetabolismAntifungal resistance and susceptibilityPharmaceutical studies and practices03 medical and health sciences0302 clinical medicineHumansTriazolesDrug InteractionsAntifungal AgentsAdultModels, BiologicalObesityMaleFemaleHalf-LifeCytochrome P-450 CYP3ACytochrome P-450 CYP3A InhibitorsHealthy VolunteersBody WeightMiddle AgedYoung AdultBody Mass Index

MeSH Terms

AdultAntifungal AgentsBody WeightDrug InteractionsFemaleHalf-LifeHumansMaleMiddle AgedModels, BiologicalObesityTriazolesBody Mass IndexCytochrome P-450 CYP3AYoung AdultHealthy VolunteersCytochrome P-450 CYP3A Inhibitors

Keywords

PosaconazolePharmacologyPharmacokineticsMedicineTherapeutic drug monitoringConcomitantPharmacodynamicsDosingDrugCYP3A4ItraconazoleInternal medicineAntifungalCytochrome P450DermatologyObesitydrug-drug interactionsPhysiologically-based Pharmacokinetic ModelingAdultMaleOriginal PaperAntifungal AgentsBody WeightTriazolesMiddle AgedModels, BiologicalHealthy VolunteersBody Mass IndexYoung AdultHumansCytochrome P-450 CYP3ACytochrome P-450 CYP3A InhibitorsDrug InteractionsFemaleHalf-Life

Sustainable Development Goals

SDG 0: Good health and well-being