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The Role of Constitutive Androstane Receptor in Oxazaphosphorine-Mediated Induction of Drug-Metabolizing Enzymes in Human Hepatocytes

Pharmaceutical Research(2011)10.1007/s11095-011-0429-2Source: DataRank Database

The Role of Constitutive Androstane Receptor in Oxazaphosphorine-Mediated Induction of Drug-Metabolizing Enzymes in Human Hepatocytes is a research paper published in Pharmaceutical Research (2011). On theSindex it has a DataRank of 0.477. It has been cited 23 times.

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0.477DataRank · unranked

Scored on demand from live citation data

23 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 2.87)OA: closedTopics (58)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.477

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (5)

Linhao Li ORCID,Jennifer Fuhrman,Stephen Ferguson ORCID,Hongbing Wang ORCID,Duan Wang ORCID

Live enrichment

PubMed:21487929 PMC:PMC3703447 OpenAlex:https://openalex.org/W1973422270

NIDDK NIH HHS

Grant: R01 DK061652

National Institutes of Health

Grant: 5R01DK061652-12

Regulation of CYP2B6 in Human Liver

FWCI

2.87

Citation Percentile

0.9%

Citation Trend

2012

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2023

closedLicense: Springer TDM

publisherhttp://link.springer.com/content/pdf/10.1007/s11095-011-0429-2.pdf

publisherhttp://link.springer.com/article/10.1007/s11095-011-0429-2/fulltext.html

publisherhttp://link.springer.com/content/pdf/10.1007/s11095-011-0429-2

journalhttps://doi.org/10.1007/s11095-011-0429-2

repositoryhttps://pubmed.ncbi.nlm.nih.gov/21487929

Fields of Study

Pharmacogenetics and Drug MetabolismChemotherapy-induced organ toxicity mitigationDrug-Induced Hepatotoxicity and Protection0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Pregnane X ReceptorConstitutive Androstane ReceptorAryl Hydrocarbon HydroxylasesCells, CulturedCyclophosphamideDrug InteractionsEnzyme InductionHumansIfosfamideLiverInactivation, MetabolicOxidoreductases, N-DemethylatingReceptors, SteroidReceptors, Cytoplasmic and NuclearReceptors, Aryl HydrocarbonHepatocytesCytochrome P-450 CYP3AHep G2 CellsCytochrome P-450 CYP2B6

Keywords

Constitutive androstane receptorDrugEnzymePharmacologyEnzyme inducerReceptorCytochrome P450AndrostaneChemistryBiologyBiochemistryNuclear receptorEndocrinologyTranscription factorGeneReceptors, SteroidPregnane X ReceptorReceptors, Cytoplasmic and NuclearOxidoreductases, N-DemethylatingHep G2 CellsCytochrome P-450 CYP2B6LiverReceptors, Aryl HydrocarbonEnzyme InductionInactivation, MetabolicHepatocytesCytochrome P-450 CYP3AHumansDrug InteractionsAryl Hydrocarbon HydroxylasesIfosfamideCyclophosphamideCells, Cultured

Sustainable Development Goals

SDG 0: Good health and well-being

The Role of Constitutive Androstane Receptor in Oxazaphosphorine-Mediated Induction of Drug-Metabolizing Enzymes in Human Hepatocytes

FAIR Checklist

DataRank Breakdown

Authors (5)

Funding (2 grants)

Impact

Open Access

Topics