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A CRISPR/Cas9 assisted strategy for the conditional expression of human NF-kappaB c-Rel cDNA in mouse T cells: design, prospects, and challenges

Transgenic Research(2025)10.1007/s11248-025-00470-9Source: DataRank Database

A CRISPR/Cas9 assisted strategy for the conditional expression of human NF-kappaB c-Rel cDNA in mouse T cells: design, prospects, and challenges is a research paper published in Transgenic Research (2025). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)Impact (FWCI 0.00)OA: closedTopics (43)IDs (PubMed, OpenAlex)

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Findable (1/2)

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Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Joshua T Centore,Shashank Shukla ORCID,Julia Hluck,Ronald A. Conlon ORCID,Parameswaran Ramakrishnan ORCID

Live enrichment

PubMed:41410797 OpenAlex:https://openalex.org/W4417497723

NIDDK NIH HHS

Grant: R01 DK128463

BLRD VA

Grant: I01 BX005941

NIAID NIH HHS

Grant: R01 AI116730

FWCI

0.00

Citation Percentile

0.3%

closedLicense: https://www.springernature.com/gp/researchers/text-and-data-mining

publisherhttps://link.springer.com/content/pdf/10.1007/s11248-025-00470-9.pdf

publisherhttps://link.springer.com/article/10.1007/s11248-025-00470-9/fulltext.html

journalhttps://doi.org/10.1007/s11248-025-00470-9

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41410797

Fields of Study

NF-κB Signaling PathwaysDiabetes and associated disordersT-cell and B-cell ImmunologyAnimalsHumansMiceCRISPR-Cas SystemsMice, TransgenicProto-Oncogene Proteins c-relPromoter Regions, GeneticMice, Inbred NODGene EditingT-LymphocytesDNA, ComplementaryDiabetes Mellitus, Type 1NF-kappa B

MeSH Terms

Gene EditingAnimalsDiabetes Mellitus, Type 1HumansMice, TransgenicPromoter Regions, GeneticT-LymphocytesNF-kappa BMice, Inbred NODDNA, ComplementaryProto-Oncogene Proteins c-relMiceCRISPR-Cas Systems

Keywords

TransgeneGenetically modified mouseComplementary DNAGeneTranscription (linguistics)Transcription factorGene targetingRegulation of gene expressionRegulatory sequenceNF-κBtype 1 diabetesEpigenetic SilencingConditional Knock-inCrispr-cas9 Gene Editing

A CRISPR/Cas9 assisted strategy for the conditional expression of human NF-kappaB c-Rel cDNA in mouse T cells: design, prospects, and challenges

FAIR Checklist

Authors (6)

Funding (3 grants)

Impact

Open Access

Topics