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Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model

GeroScience(2024)10.1007/s11357-024-01137-9Source: DataRank Database

Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model is a research paper published in GeroScience (2024). On theSindex it has a DataRank of 0.372. It has been cited 7 times, with 7 citing works in its 1-hop citation network.

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0.372DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access7 citations · 7 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

BioProjectPRJNA0989703

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 1.15)OA: hybridTopics (61)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 84%Citation Network 16%

Base Score Contribution

0.312

From this paper's citation signal

Citation Network Contribution

0.0599

From 3 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 7 citers.

Absorption to Excretion: The Aging Body’s Take on Drugs – A Review of Pharmacokinetic Changes and their Impact on Medication Management
Current Pharmacology Reports202524 citations66 referencesContributes 0.049
A functional ancestry-linked regulatory haplotype influences CYP2D6 expression
The Pharmacogenomics Journal20261 citations50 referencesContributes 0.014
Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration
Clinical Epigenetics20254 citations205 referencesContributes 0.008
Omics Integration in Understanding Xenobiotic Metabolism
20250 citations106 referencesContributes 0.000
Metabolic–Epigenetic Crosstalk in Takayasu Arteritis: The ANK2–MAVS–IL-8 Axis as a Novel Therapeutic Paradigm
International Journal of Molecular Sciences20260 citations131 referencesContributes 0.000

Authors (18)

Mohamad M. Kronfol ORCID,Mikhail G. Dozmorov ORCID,Thomas Campbell ORCID,Fay M. Jahr,Jasmine Nguyen ORCID

Live enrichment

PubMed:38558216 PMC:PMC11493898 OpenAlex:https://openalex.org/W4393375483

National Institute on Aging

Grant: R15AG061649

National Institutes of Health

Grant: 1R15AG061649-01

Effects of aging on epigenetic regulation of drug metabolism

FWCI

1.15

Citation Percentile

0.8%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://link.springer.com/content/pdf/10.1007/s11357-024-01137-9.pdf

publisherhttps://link.springer.com/content/pdf/10.1007/s11357-024-01137-9.pdf

publisherhttps://link.springer.com/article/10.1007/s11357-024-01137-9/fulltext.html

journalhttps://doi.org/10.1007/s11357-024-01137-9

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38558216

Fields of Study

Epigenetics and DNA MethylationGenetics and Neurodevelopmental DisordersDiet and metabolism studies0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsDNA MethylationAgingLiverEpigenesis, GeneticXenobioticsMultidrug Resistance-Associated Protein 2MiceMaleGenome-Wide Association StudyMice, Inbred C57BLHepatocyte Nuclear Factor 4ATP-Binding Cassette, Sub-Family C Proteins

MeSH Terms

Multidrug Resistance-Associated Protein 2AgingAnimalsLiverMaleMice, Inbred C57BLXenobioticsDNA MethylationMultidrug Resistance-Associated ProteinsATP-Binding Cassette, Sub-Family C ProteinsEpigenesis, GeneticMiceHepatocyte Nuclear Factor 4Genome-Wide Association Study

Keywords

EpigeneticsBiologyDNA methylationDrug metabolismGeneticsGeneMethylationGene expressionMultidrug resistance-associated protein 2TransporterATP-binding cassette transporterMetabolismBiochemistryAgingCytochrome P450sHepatic TransportersHepatic Xenobiotic MetabolismMaleATP-Binding Cassette, Sub-Family C ProteinsEpigenesis, GeneticXenobioticsMice, Inbred C57BLMiceLiverHepatocyte Nuclear Factor 4AnimalsOriginal ArticleGenome-Wide Association Study

Sustainable Development Goals

SDG 0: Good health and well-being