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Selective Induction of Cellular Toxicity and Anti-tumor Efficacy by N-Methylpiperazinyl Diarylidenylpiperidone and its Pro-nitroxide Conjugate through ROS-mediated Mitochondrial Dysfunction and G2/M Cell-cycle Arrest in Human Pancreatic Cancer

Cell Biochemistry and Biophysics(2020)10.1007/s12013-020-00919-0Source: DataRank Database

Selective Induction of Cellular Toxicity and Anti-tumor Efficacy by N-Methylpiperazinyl Diarylidenylpiperidone and its Pro-nitroxide Conjugate through ROS-mediated Mitochondrial Dysfunction and G2/M Cell-cycle Arrest in Human Pancreatic Cancer is a research paper published in Cell Biochemistry and Biophysics (2020). On theSindex it has a DataRank of 0. It has been cited 23 times.

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Scored on demand from live citation data

23 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 1.56)OA: closedTopics (82)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (0/2)

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

John W. Hinds,Dan Tse,Katherine S. Axelrod,M. Lakshmi Kuppusamy,Maciej M. Kmieć

Live enrichment

PubMed:32449075 OpenAlex:https://openalex.org/W3026616199

National Institutes of Health

Grant: EB004031

National Institutes of Health

Grant: 5R01EB004031-11

Probes and Methods for Clinical Oximetry

FWCI

1.56

Citation Percentile

0.8%

Citation Trend

2020

2021

2023

2025

closedLicense: Springer TDM

publisherhttps://link.springer.com/content/pdf/10.1007/s12013-020-00919-0.pdf

publisherhttps://link.springer.com/article/10.1007/s12013-020-00919-0/fulltext.html

journalhttps://doi.org/10.1007/s12013-020-00919-0

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32449075

https://dx.doi.org/10.1007/s12013-020-00919-0

Fields of Study

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology ResearchDrug Transport and Resistance Mechanisms0301 basic medicine03 medical and health sciences0302 clinical medicineAnimalsAntineoplastic AgentsApoptosisCell CycleCell DivisionCell Line, TumorCell SurvivalDrug Screening Assays, AntitumorElectron Spin Resonance SpectroscopyG2 PhaseHumansMiceMice, Inbred NODMice, SCIDMitochondriaNeoplasm TransplantationOximetryPancreatic NeoplasmsPiperazinesPiperidonesReactive Oxygen Species

MeSH Terms

AnimalsAntineoplastic AgentsCell CycleCell DivisionCell SurvivalDrug Screening Assays, AntitumorElectron Spin Resonance SpectroscopyHumansMitochondriaNeoplasm TransplantationOximetryPancreatic NeoplasmsPiperazinesPiperidonesG2 PhaseMice, SCIDMice, Inbred NODApoptosisReactive Oxygen SpeciesCell Line, TumorMice

Keywords

Pancreatic cancerCancer researchApoptosisCell cycleCell cycle checkpointMedicineCancerPharmacologyChemistryInternal medicineBiochemistryROSXenograft tumorNitroxideDiarylidenylpiperidoneTumor OxygenG2 PhaseCell SurvivalElectron Spin Resonance SpectroscopyAntineoplastic AgentsMice, SCIDPiperazinesMitochondriaPancreatic NeoplasmsMiceMice, Inbred NODCell Line, TumorAnimalsHumansOximetryDrug Screening Assays, AntitumorCell DivisionNeoplasm TransplantationPiperidones

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being