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How to make an undruggable enzyme druggable: lessons from ras proteins

Advances in protein chemistry and structural biology(2020)10.1016/bs.apcsb.2020.05.003Source: DataRank Database

How to make an undruggable enzyme druggable: lessons from ras proteins is a research paper published in Advances in protein chemistry and structural biology (2020). On theSindex it has a DataRank of 0. It has been cited 9 times.

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9 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)Impact (FWCI 0.78)OA: closedTopics (26)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, OpenAlex)SDGs (1)

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Context only (not used in score)

Findable (2/2)

Has DOI
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Accessible (0/2)

Interoperable (2/2)

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Reusable (0/3)

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Authors (2)

Alemayehu A. Gorfe ORCID,Abdallah Sayyed–Ahmad ORCID

Live enrichment

PubMed:32951811 OpenAlex:https://openalex.org/W3037825825

Cancer Prevention and Research Institute of Texas

Grant: RP190366

National Institutes of Health

Grant: R01GM124233

FWCI

0.78

Citation Percentile

0.7%

Citation Trend

2023

2024

2025

2026

closedLicense: https://doi.org/10.15223/policy-004

publisherhttps://api.elsevier.com/content/article/PII:S1876162320300511?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1876162320300511?httpAccept=text/plain

book serieshttps://doi.org/10.1016/bs.apcsb.2020.05.003

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32951811

Fields of Study

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancerMelanoma and MAPK Pathways

MeSH Terms

Antineoplastic AgentsEnzyme InhibitorsHumansNeoplasm ProteinsNeoplasmsSignal TransductionDrug Delivery Systemsras ProteinsComputational Biology

Keywords

DruggabilityAllosteric regulationComputational biologyDrug discoveryBiologyEnzymeChemistryBiochemistryGeneDrug designRas oncogenesAllosteric InhibitorsBinding Site IdentificationMembrane-bound Proteins

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 1 of Prospective virtual screening combined with bio-molecular simulation enabled identification of new inhibitors for the KRAS drug target

10.6084/m9.figshare.25478857.v1figshare

Additional file 1 of Prospective virtual screening combined with bio-molecular simulation enabled identification of new inhibitors for the KRAS drug target

10.6084/m9.figshare.25478857figshare

How to make an undruggable enzyme druggable: lessons from ras proteins

FAIR Checklist

Authors (2)

Funding (2 grants)

Impact

Open Access

Topics

Linked Datasets (2)