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Mutational analysis confirms the presence of distal inhibitor-selectivity determining residues in B. stearothermophilus dihydrofolate reductase

Archives of Biochemistry and Biophysics(2020)10.1016/j.abb.2020.108545Source: DataRank Database

Mutational analysis confirms the presence of distal inhibitor-selectivity determining residues in B. stearothermophilus dihydrofolate reductase is a research paper published in Archives of Biochemistry and Biophysics (2020). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)Impact (FWCI 0.00)OA: greenTopics (34)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Seema Patel ORCID,Thomas Candela ORCID,Katherine Leon H.,Michael S. Little,Natalia E. Reis

Live enrichment

PubMed:32810476 PMC:PMC10727455 OpenAlex:https://openalex.org/W3049739629

National Science Foundation

Grant: DUE-1458499

National Institutes of Health

Grant: 1R15GM126467-01

Investigation of Substrate Specificity, Mechanism, and Inhibition of IGPS

NIGMS NIH HHS

Grant: R15 GM126467

National Science Foundation

Grant: 1458499

Opening Pathways, Engaging, and Networking in Chemistry in Northern New Jersey (OPEN-NJ)

Montclair State University

FWCI

0.00

Citation Percentile

0.1%

greenLicense: Elsevier TDM

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10727455/pdf/nihms-1626261.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0003986120305543?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0003986120305543?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10727455

Fields of Study

HIV/AIDS drug development and treatmentTuberculosis Research and EpidemiologyRNA and protein synthesis mechanisms0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Geobacillus stearothermophilusBacterial ProteinsFolic Acid AntagonistsTetrahydrofolate DehydrogenaseAmino Acid SubstitutionMutation, Missense

Keywords

Dihydrofolate reductaseActive siteSelectivityHomology modelingBinding siteStereochemistryChemistryEnzymeBiochemistryBiologyTrimethoprimPyrimethamineDhfrDrug BindingInhibitor SelectivityDistal ResiduesGeobacillus stearothermophilusTetrahydrofolate DehydrogenaseAmino Acid SubstitutionBacterial ProteinsMutation, MissenseFolic Acid Antagonists

Sustainable Development Goals

SDG 0: Good health and well-being