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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

The American Journal of Human Genetics(2022)10.1016/j.ajhg.2022.06.012Source: DataRank Database

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids is a research paper published in The American Journal of Human Genetics (2022). On theSindex it has a DataRank of 0.626. It has been cited 64 times.

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Enrichment:Funding (85 grants)OA: bronzeTopics (107)Linked Datasets (24)DataCite Reuse (24)IDs (PubMed, PMC)Annotations (1)SDGs (1)

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Authors (100)

Jonathan Judd ORCID,Sarah E. Graham ORCID,Stavroula Kanoni ORCID,Yuxuan Wang ORCID,Ida Surakka ORCID

Live enrichment

PubMed:35931049 PMC:PMC9388392

Economic and Social Research Council

Grant: ES/S007253/1

NNF Center for Basic Metabolic Research

Grant: Grarup Group

Novo Nordisk Fonden

Grant: NNF14OC0010513

NIA NIH HHS

Grant: P30 AG072975

NCI NIH HHS

Grant: R01 CA144034

NHLBI NIH HHS

Grant: R01 HL109946

NHLBI NIH HHS

Grant: R01 HL133218

NHGRI NIH HHS

Grant: U54 HG006938

National Institute for Health Research (NIHR)

Grant: CL-2021-25-004

NNF Center for Basic Metabolic Research

Grant: Phenomics

Medical Research Council

Grant: MC_U137686851

Medical Research Council

Grant: MR/R024227/1

Medical Research Council

Grant: MR/S011676/1

Medical Research Council

Grant: MR/S019669/1

NIDDK NIH HHS

Grant: P30 DK020541

NIDDK NIH HHS

Grant: R01 DK075787

NHGRI NIH HHS

Grant: R01 HG006399

NHGRI NIH HHS

Grant: R21 HG010952

NHGRI NIH HHS

Grant: U01 HG011172

Medical Research Council

Grant: HDR-9004

Novo Nordisk Fonden

Grant: NNF18OC0033898

NIA NIH HHS

Grant: R01 AG065357

NIDDK NIH HHS

Grant: R01 DK093757

NHLBI NIH HHS

Grant: R01 HL127564

NHGRI NIH HHS

Grant: T32 HG000040

NCI NIH HHS

Grant: U01 CA261339

NIDDK NIH HHS

Grant: U01 DK062370

NHGRI NIH HHS

Grant: U01 HG011723

Medical Research Council

Grant: MC_PC_13049

Medical Research Council

Grant: MC_UU_00007/10

Medical Research Council

Grant: MC_UU_00017/1

National Institute for Health Research (NIHR)

Grant: NF-SI-0611-10170

Novo Nordisk Fonden

Grant: NNF13OC0005785

Novo Nordisk Fonden

Grant: NNF19OC0055250

NIDDK NIH HHS

Grant: P30 DK020572

NHLBI NIH HHS

Grant: R01 HL153805

NHLBI NIH HHS

Grant: R35 HL135818

British Heart Foundation

Grant: RG/13/13/30194

BLRD VA

Grant: I01 BX003362

BLRD VA

Grant: I01 BX004821

NIGMS NIH HHS

Grant: R01 GM140287

British Heart Foundation

Grant: RG/18/13/33946

Wellcome Trust

Grant: 210561/Z/18/Z

Wellcome Trust

Grant: 212946/Z/18/Z

NNF Center for Basic Metabolic Research

Grant: CBMR - 008

Medical Research Council

Grant: G0601463

CSRD VA

Grant: IK2 CX001780

Medical Research Council

Grant: MC_PC_14135

Medical Research Council

Grant: MC_UU_12026/2

NIDDK NIH HHS

Grant: R01 DK062370

NHLBI NIH HHS

Grant: R03 HL154284

Wellcome Trust

Grant: 212945/Z/18/Z

Wellcome Trust

Grant: 221854/Z/20/Z

British Heart Foundation

Grant: CH/12/2/29428

Economic and Social Research Council

Grant: ES/L008459/1

Medical Research Council

Grant: MC_PC_20026

Medical Research Council

Grant: MC_UU_00006/1

Novo Nordisk Fonden

Grant: NNF20OC0059313

NCI NIH HHS

Grant: R01 CA080205

NIDDK NIH HHS

Grant: R01 DK072193

NHLBI NIH HHS

Grant: R01 HL105756

Public Health Agency

Grant: STL/5569/19

NCI NIH HHS

Grant: UM1 CA182876

Swiss National Science Foundation

Grant: 204523

Prospective associations of major depressive disorder with atherosclerotic cardiovascular disease, cognitive impairment and mortality in the community

Wellcome Trust

Grant: 217065

The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being.

Swiss National Science Foundation

Grant: 105993

Psychiatric disorders in 35 to 65 year-old residents of the city of Lausanne and their association to cardiovasular risk factors: a population based survey

National Institutes of Health

Grant: 5R01HL133218-03

Epigenetic fine-mapping of cardiometabolic disease loci in the human liver

Swiss National Science Foundation

Grant: 118308

Family study of specific subthreshold and threshold mood, anxiety, substance use and schizophrenia spectrum syndromes in the general population

Research Council of Finland

Grant: 312062

Center of Excellence in Complex Disease Genetics-from Discovery to Precision Medicine / Consortium: CoECDG

European Commission

Grant: 608765

WILLIAM HARVEY INTERNATIONAL TRANSLATIONAL RESEARCH ACADEMY

Swiss National Science Foundation

Grant: 220190

Effects of sex and gender on cardiovascular risk factors and mental disorders in a middle-aged population-based cohort

Swiss National Science Foundation

Grant: 189130

Associations between depression and obesity markers in adolescents and young adults in the community

National Institutes of Health

Grant: 1I01BX004821-01A1

Cardiovascular Disease Risk Factors, Cardiovascular Disease Risk Prediction, and Genetics in the Million Veteran Program

Wellcome Trust

Grant: 201543

An integrated approach to the muscle Z-disk: from atomic structure to human disease

National Institutes of Health

Grant: 2R01HL142302-05A1

Hispanic Latino Lipid Consortium

European Commission

Grant: 786833

GENetics and the Electrocardiogram for predicting Scd rISk

National Institutes of Health

Grant: 5R01HL142711-07

Whole genome sequences in ethnically diverse individuals to comprehensively characterize the genetic mechanisms of dyslipidemias

Swiss National Science Foundation

Grant: 139468

Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study

Swiss National Science Foundation

Grant: 122661

Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study

European Commission

Grant: 601456

Exploitation of genomic variants affecting coronary artery disease and stroke risk for therapeutic intervention

National Institutes of Health

Grant: 2I01BX003362-03A1

Genetics of Cardiometabolic Diseases in the VA Population

Swiss National Science Foundation

Grant: 177535

Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study

Wellcome Trust

Grant: 202802

What lies behind the causal impact of body mass index (BMI) level and change on human health? Added value from complementary study design and deep metabolomic phenotyping.

Swiss National Science Foundation

Grant: 148401

Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study

National Institutes of Health

Grant: 5R01HL127564-06

Using genetic variation to study biology of blood lipids & coronary heart disease

bronzeLicense: CC BY

publisherhttp://www.cell.com/article/S0002929722002658/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0002929722002658?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0002929722002658?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9388392

repositoryhttps://hdl.handle.net/1983/5b8d5f84-7a3a-4e95-9f06-f5e23349c04c

Fields of Study

0303 health sciences03 medical and health sciences0301 basic medicineChromatinGenome-Wide Association StudyGenomicsHumansLipidsPolymorphism, Single Nucleotide

MeSH Terms

ChromatinHumansLipidsGenomicsPolymorphism, Single NucleotideGenome-Wide Association Study

Keywords

Functional genomicsRegulatory mechanismComplex TraitsFine-mappingVariant PrioritizationPost-gwasLipid Biologygenetic analysislipid blood levelgenetic riskwhole exome sequencingCromatinafunctional genomicgeneticsAetiologyGenome-Wide Association Study*Genetics & HeredityChromatin/geneticsRadboudumc 12: Sensory disorders DCMN: Donders Center for Medical NeuroscienceGenomicsLipidsChromatincomplex traits; fine-mapping; functional genomics; lipid biology; post-GWAS; regulatory mechanism; variant prioritization; Chromatin; Genomics; Humans; Lipids; Genome-Wide Association Study; Polymorphism, Single Nucleotidename=Genetics(clinical)complex traitLípidoscomplex traits; fine-mapping; functional genomics; lipid biology; post-GWAS; regulatory mechanism; variant prioritization.Single Nucleotide/geneticssingle cell RNA seq/dk/atira/pure/subjectarea/asjc/1300/1311572/dk/atira/pure/subjectarea/asjc/2700/2716; name=Genetics(clinical)phenotypename=Genetics610ta3111Article576lipidHumanshumanPolymorphismbinding siteLipids/geneticsgenetic variationUrology - Radboud University Medical Centerchemical structurecholesterol metabolismHuman Genetics - Radboud University Medical CentertranscriptomePolimorfismo de nucleótido simpleMedizinMedical and Health SciencesINTEGRATIVE ANALYSIS ; WIDE ASSOCIATION ; 3D GENOME ; VARIANTS ; CHOLESTEROL ; ANNOTATION ; OBESITY ; COMMON ; LOCI ; EXPRESSIONLipids / geneticssingle nucleotide polymorphismbinding affinity2.1 Biological and endogenous factorstranscription factorChromatin/genetics; Genome-Wide Association Study; Genomics; Humans; Lipids/genetics; Polymorphism, Single Nucleotide/genetics; complex traits; fine-mapping; functional genomics; lipid biology; post-GWAS; regulatory mechanism; variant prioritizationGlobal Lipids Genetics ConsortiumSingle NucleotideBiological SciencesPolymorphism, Single Nucleotide/geneticsretinoid X receptor alphaComplex Traits ; Fine-mapping ; Functional Genomics ; Lipid Biology ; Post-gwas ; Regulatory Mechanism ; Variant PrioritizationEstudio de asociación del Genomaddc:570triacylglycerolBiotechnologyHealth Evidence - Radboud University Medical CenterGenómicacomplex traits; fine-mapping; functional genomics; lipid biology; post-GWAS; regulatory mechanism; variant prioritizationRadboudumc 15: Urological cancers RIHS: Radboud Institute for Health Sciencesgene frequencyPolymorphism, Single NucleotideadipogenesisRadboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciencespost-genome-wide association studies (GWASs)/dk/atira/pure/subjectarea/asjc/1300/1311; name=Geneticsgenome-wide association studyHuman GenomeMillion Veterans Program/dk/atira/pure/subjectarea/asjc/2700/2716Single Nucleotide* / geneticsWnt signaling3111cell differentiationChromatin / geneticsgene expressionInstitut für Ernährungswissenschaftuntranslated RNA

Sustainable Development Goals

SDG 3: 3. Good health

Dataset_CoLaus|PsyCoLaus_study_and_satellite_studies

10.5281/zenodo.19202099Zenodo

Dataset_CoLaus|PsyCoLaus_study_and_satellite_studies

10.5281/zenodo.19202098Zenodo

Additional file 2 of Genetic effects of sequence-conserved enhancer-like elements on human complex traits

10.6084/m9.figshare.24934550.v1figshare

Additional file 2 of Genetic effects of sequence-conserved enhancer-like elements on human complex traits

10.6084/m9.figshare.24934550figshare

Additional file 3 of Genetic effects of sequence-conserved enhancer-like elements on human complex traits

10.6084/m9.figshare.26658229.v1figshare

Additional file 3 of Genetic effects of sequence-conserved enhancer-like elements on human complex traits

10.6084/m9.figshare.26658229figshare

Additional file 7 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743151.v1figshare

Additional file 7 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743151figshare

Additional file 8 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743154.v1figshare

Additional file 8 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743154figshare

Additional file 5 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743145figshare

Additional file 6 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743148figshare

Additional file 3 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743139figshare

Additional file 6 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743148.v1figshare

Additional file 3 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743139.v1figshare

Additional file 4 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743142.v1figshare

Additional file 4 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743142figshare

Additional file 5 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26743145.v1figshare

Additional file 2 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26182312.v1figshare

Additional file 2 of Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study

10.6084/m9.figshare.26182312figshare

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

FAIR Checklist

DataRank Breakdown

Authors (100)

Funding (85 grants)

Open Access

Topics

Linked Datasets (24)

Annotations (Europe PMC)