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Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension

Acta Pharmaceutica Sinica B(2020)10.1016/j.apsb.2020.09.009Source: DataRank Database

Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension is a research paper published in Acta Pharmaceutica Sinica B (2020). On theSindex it has a DataRank of 0. It has been cited 60 times.

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Enrichment:Funding (2 grants)Impact (FWCI 1.57)OA: goldTopics (72)Linked Datasets (12)DataCite Reuse (12)IDs (PubMed, OpenAlex)SDGs (2)

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Accessible (1/2)

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Interoperable (2/2)

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Authors (3)

Maarten P. Koeners ORCID,Jinwei Zhang ORCID,Nur Farah Meor Azlan

Live enrichment

PubMed:34094823 OpenAlex:https://openalex.org/W3088227706

National Institutes of Health

Grant: R01 NS109358

National Institutes of Health

Grant: 7R01NS109358-05

Modulation of Choroid Plexus Immuno-secretory Function to Restore Cerebrospinal Fluid Homeostasis in Hydrocephalus

FWCI

1.57

Citation Percentile

0.8%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

goldLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.apsb.2020.09.009

publisherhttps://doi.org/10.1016/j.apsb.2020.09.009

publisherhttps://api.elsevier.com/content/article/PII:S2211383520307206?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S2211383520307206?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34094823

Fields of Study

Ion Transport and Channel RegulationHormonal Regulation and HypertensionIon channel regulation and function0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Distal convoluted tubuleKinaseRegulatorMedicineOxidative stressInternal medicineEndocrinologyChemistryCell biologyBiologyBioinformaticsBiochemistryReabsorptionKidney570Blood pressure regulationNaCl-cotransporter NCC610Membrane traffickingRM1-950ReviewCardiovascular diseaseCUL3/KLHL3-WNK-SPAK/OSR1Kinase inhibitorsHypertensionTherapeutic targetsTherapeutics. PharmacologyATP, adenosine triphosphateCCC, cation-coupled chloride cotransportersCCT, conserved carboxy-terminalCNI, calcineurin inhibitorsCUL3, cullin 3Ca2+, calcium ionDAG, diacylglycerolDCT, distal convoluted tubuleDUSP, dual specificity phosphatasesECF, extracellular fluidELISA, enzyme-bound immunosorbent analysisERK, extracellular signal-regulated kinasesEnaC, epithelial sodium channelsGABA, gamma-aminobutyric acidHEK293, human embryonic kidney 293I1, inhibitor 1K+, potassium ionKCC, potassium-chloride-cotransportersKLHL3, kelch-like 3KS-WNK1, kidney specific-WNK1MAPK, mitogen-activated protein kinaseMO25, mouse protein-25NCC, sodium–chloride cotransportersNKCC, sodium–potassium–chloride-cotransporterNa+, sodium ionNaCl, sodium chlorideOSR1, oxidative stress-responsive gene 1PCT, proximal convoluted tubulePHAII, pseudohypoaldosteronism type IIPP, protein phosphatasePV, parvalbuminROMK, renal outer medullary potassiumRasGRP1, RAS guanyl-releasing protein 1SLC12, solute carrier 12SPAK, Ste20-related proline-alanine-rich-kinaseTAL, thick ascending limbWNK, with-no-lysine kinasesmDCT, mammalian DCTmRNA, messenger RNA

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735262.v1figshare

Additional file 1 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735262figshare

Additional file 2 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735265.v1figshare

Additional file 2 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735265figshare

Additional file 3 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735268.v1figshare

Additional file 3 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735268figshare

Additional file 4 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735271.v1figshare

Additional file 4 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735271figshare

Additional file 5 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735274.v1figshare

Additional file 5 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735274figshare

Additional file 6 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735277.v1figshare

Additional file 6 of Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis

10.6084/m9.figshare.26735277figshare

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