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Discovery of small molecule positive allosteric modulators of the secretin receptor

Biochemical Pharmacology(2021)10.1016/j.bcp.2021.114451Source: DataRank Database

Discovery of small molecule positive allosteric modulators of the secretin receptor is a research paper published in Biochemical Pharmacology (2021). On theSindex it has a DataRank of 0. It has been cited 14 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access14 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.67)OA: greenTopics (69)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Kaleeckal G. Harikumar ORCID,Sirkku Pollari,Qing Sun ORCID,Brock Brown,Aki Shinoki-Iwaya

Live enrichment

PubMed:33545115 PMC:PMC8146373 OpenAlex:https://openalex.org/W3127425425

National Heart, Lung, and Blood Institute

Grant: HL133501

NCI NIH HHS

Grant: P30 CA030199

NHLBI NIH HHS

Grant: R01 HL133501

National Institutes of Health

Grant: 5R01HL133501-05

Activation of the Secretin Receptor as a Strategy for the Treatment of Heart Failure

National Institutes of Health

FWCI

0.67

Citation Percentile

0.7%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8146373

publisherhttps://api.elsevier.com/content/article/PII:S0006295221000472?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0006295221000472?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bcp.2021.114451

Fields of Study

Receptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyLipid Membrane Structure and Behavior0301 basic medicine0303 health sciences03 medical and health sciencesAllosteric RegulationAmino Acid SequenceAnimalsCHO CellsCell Line, TumorCricetinaeCricetulusDose-Response Relationship, DrugDrug DiscoveryHEK293 CellsHumansProtein BindingPyrimidinesRatsReceptors, G-Protein-CoupledReceptors, Gastrointestinal HormoneStructure-Activity Relationship

MeSH Terms

Allosteric RegulationAmino Acid SequenceAnimalsCricetulusDose-Response Relationship, DrugCricetinaeHumansProtein BindingPyrimidinesReceptors, Gastrointestinal HormoneStructure-Activity RelationshipCHO CellsReceptors, G-Protein-CoupledCell Line, TumorRatsDrug DiscoveryHEK293 Cells

Keywords

Allosteric regulationSmall moleculeSecretinChemistryAllosteric modulatorReceptorBiophysicsBiochemistryBiologyStereochemistryG protein-coupled receptorPositive Allosteric ModulatorSecretin ReceptorDose-Response Relationship, DrugCHO CellsRatsReceptors, G-Protein-CoupledReceptors, Gastrointestinal HormoneStructure-Activity RelationshipCricetulusHEK293 CellsPyrimidinesCell Line, TumorCricetinaeDrug DiscoveryAnimalsHumansAmino Acid SequenceProtein Binding

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being