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Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature

Biochemical Pharmacology(2021)10.1016/j.bcp.2021.114698Source: DataRank Database

Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature is a research paper published in Biochemical Pharmacology (2021). On theSindex it has a DataRank of 0. It has been cited 51 times.

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Open Access51 citations

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Gut microbiome analysis of high fat diet- and control-fed on PXR-KO mice · Dryad

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (21 grants)Impact (FWCI 5.28)OA: greenTopics (83)Linked Datasets (1)DataCite Reuse (1)IDs (PubMed, PMC, OpenAlex)SDGs (3)

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Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (9)

Sora Choi,Moumita Dutta ORCID,Jeffrey O. Asubonteng,Marianne Polunas ORCID,Michael Goedken

Live enrichment

PubMed:34303710 PMC:PMC9135326 OpenAlex:https://openalex.org/W3123898016

National Institutes of Health

Grant: 1U54MD012392

National Institutes of Health

Grant: ES025708

National Institutes of Health

Grant: ES031098

National Institutes of Health

Grant: P30 ES007033

National Institutes of Health

Grant: R01 AA028806

National Institutes of Health

Grant: R01 ES030197

National Institutes of Health

Grant: U54 AA019765

National Cancer Institute

Grant: DK056350

National Cancer Institute

Grant: P30DK05635

NIEHS NIH HHS

Grant: R01 ES031098

NIMHD NIH HHS

Grant: U54 MD012392

NIDDK NIH HHS

Grant: P30 DK056350

NIEHS NIH HHS

Grant: P30 ES005605

NIEHS NIH HHS

Grant: R01 ES025708

Wellcome Trust

Grant: unidentified

unidentified

National Institutes of Health

Grant: 1U54MD012392-01

RCMI Center for Health Disparities Research

National Institutes of Health

Grant: 3P30ES007033-18S1

Center for Ecogenetics and Environmental Health

National Institutes of Health

Grant: 1R01AA028806-01

Human pregnane X receptor and sexual dimorphism in alcoholic liver disease

National Institutes of Health

Grant: 5R01ES030197-03

Developmental PBDE exposure, gut microbiome, and diabetes

National Institutes of Health

Grant: 5U54AA019765-05

Mechanisms of Alcohol Pathology: A Collaborative Partnership Between NCCU & UNC

Fundação para a Ciência e a Tecnologia, I.P.

Grant: PTDC/CCI-BIO/29266/2017

Deep Drug Discovery and Deployment

FWCI

5.28

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9135326

publisherhttps://api.elsevier.com/content/article/PII:S0006295221003117?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0006295221003117?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bcp.2021.114698

Fields of Study

Liver Disease Diagnosis and TreatmentGut microbiota and healthDiet and metabolism studies0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsBiomarkersDiet, High-FatFemaleGastrointestinal MicrobiomeGene Regulatory NetworksGlucose Tolerance TestInflammationLiverMaleMiceMice, Inbred C57BLMice, KnockoutNon-alcoholic Fatty Liver DiseaseObesityPregnane X ReceptorRNA, BacterialRNA, Ribosomal, 16SSex Factors

MeSH Terms

Gastrointestinal MicrobiomePregnane X ReceptorAnimalsFemaleGlucose Tolerance TestInflammationLiverMaleMice, Inbred C57BLObesityRNA, BacterialRNA, Ribosomal, 16SSex FactorsBiomarkersMice, KnockoutMiceGene Regulatory NetworksDiet, High-FatNon-alcoholic Fatty Liver Disease

Keywords

Pregnane X receptorNonalcoholic fatty liver diseaseSteatosisEndocrinologyInternal medicineBiologyFatty liverInflammationMicrobiomeGut floraNuclear receptorMedicineImmunologyBioinformaticsDiseaseBiochemistryTranscription factorObesitySex differencesHigh-fat dietNafldPxrGut MicrobiomeMaleMice, KnockoutGlucose Tolerance TestDiet, High-FatGastrointestinal MicrobiomeMice, Inbred C57BLMiceRNA, BacterialSex FactorsLiverNon-alcoholic Fatty Liver DiseaseRNA, Ribosomal, 16SAnimalsFemaleGene Regulatory NetworksBiomarkers

Sustainable Development Goals

SDG 2: 2. Zero hungerSDG 3: 3. Good healthSDG 0: Good health and well-being

Gut microbiome analysis of high fat diet- and control-fed on PXR-KO mice

10.5061/dryad.95x69p8jgDryad