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Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonists

Bioorganic Chemistry(2021)10.1016/j.bioorg.2021.105079Source: DataRank Database

Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonists is a research paper published in Bioorganic Chemistry (2021). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (3 grants)Impact (FWCI 0.44)OA: greenTopics (28)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Nageh A. Abou-Taleb,George G. Holz ORCID,Oleg G. Chepurny ORCID,Ioannis Pirmettis ORCID,Sotirios Kakabakos ORCID

Live enrichment

PubMed:34174633 PMC:PMC8387444 OpenAlex:https://openalex.org/W3166453378

NIDDK NIH HHS

Grant: R01 DK069575

NIDDK NIH HHS

Grant: R01 DK122332

NIH

FWCI

0.44

Citation Percentile

0.5%

Influential Citations

Citation Trend

2022

2023

2024

2026

greenLicense: https://doi.org/10.15223/policy-004

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8387444

GREENhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387444

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8387444

publisherhttps://api.elsevier.com/content/article/PII:S0045206821004569?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0045206821004569?httpAccept=text/plain

Fields of Study

Stress Responses and CortisolHormonal Regulation and HypertensionTryptophan and brain disordersMedicineChemistry

MeSH Terms

CRF Receptor, Type 1Dose-Response Relationship, DrugHumansPyrimidinesStructure-Activity RelationshipThiazolesMolecular StructureReceptors, Corticotropin-Releasing HormoneMolecular Dynamics SimulationHEK293 Cells

Keywords

ChemistryIn vitroPyrimidineReceptorPharmacologyBiological activityStereochemistryBiochemistryBiologyMolecular dynamics simulationScaffold HoppingThiazolo[4,5-d]pyrimidineCrfr1 Antagonists

Sustainable Development Goals

SDG 0: Good health and well-being

Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonists

FAIR Checklist

Authors (11)

Funding (3 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)