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A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics

Bioorganic Chemistry(2021)10.1016/j.bioorg.2021.105297Source: DataRank Database

A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics is a research paper published in Bioorganic Chemistry (2021). On theSindex it has a DataRank of 0. It has been cited 19 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access19 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 0.81)OA: greenTopics (44)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Radhika Koranne,Samkeliso Dlamini ORCID,Abdulateef Alqahtani,Endri Karaj ORCID,Maisha S. Rashid

Live enrichment

PubMed:34509798 PMC:PMC8530978 OpenAlex:https://openalex.org/W3196703635

National Institutes of Health

Grant: GM121061

National Institutes of Health

Grant: GM131821

National Institutes of Health

Grant: R15CA213185

National Institutes of Health

Grant: R15GM120712

National Institute of Environmental Health Sciences

Grant: Z01 ES043010

NIGMS NIH HHS

Grant: R01 GM121061

NIGMS NIH HHS

Grant: R35 GM131821

National Cancer Institute

FWCI

0.81

Citation Percentile

0.7%

Citation Trend

2022

2023

2024

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8530978

publisherhttps://api.elsevier.com/content/article/PII:S004520682100674X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S004520682100674X?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bioorg.2021.105297

Fields of Study

Histone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsCancer Mechanisms and Therapy

MeSH Terms

EthanolAntineoplastic AgentsCell SurvivalCytotoxinsDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansImidazolesMicrotubulesStructure-Activity RelationshipTubulinTumor Cells, CulturedMolecular StructureHCT116 CellsCell ProliferationTubulin ModulatorsPolymerization

Keywords

TubulinChemistryMitosisMicrotubule polymerizationMicrotubuleMechanism of actionDocking (animal)BiochemistryCytotoxicityCancer cellNocodazoleChalconeCell biologyIn vitroStereochemistryCellBiologyCytoskeletonCancerChalconesAnticancer AgentsMitotic SpindleAntimitotic AgentsMitotic Arrest

Sustainable Development Goals

SDG 0: Good health and well-being

A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics

FAIR Checklist

Authors (13)

Funding (8 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)