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Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity

Bioorganic Chemistry(2023)10.1016/j.bioorg.2023.106794Source: DataRank Database

Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity is a research paper published in Bioorganic Chemistry (2023). On theSindex it has a DataRank of 0.313. It has been cited 6 times, with 2 citing works in its 1-hop citation network.

N/A

0.313DataRank · unranked

Scored on demand from live citation data

Open Access6 citations · 2 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (1 grants)Impact (FWCI 0.64)OA: hybridTopics (34)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 93%Citation Network 7%

Base Score Contribution

0.292

From this paper's citation signal

Citation Network Contribution

0.0209

From 2 citing papers with measurable signal

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Authors (19)

Viviana di Giacomo ORCID,Annalisa Maruca ORCID,Vincenzo Patamia ORCID,Roberta Rocca ORCID,Maria Dichiara ORCID

Live enrichment

PubMed:37659146 OpenAlex:https://openalex.org/W4386101227

Ministero dell'Istruzione dell'Universita e della Ricerca

FWCI

0.64

Citation Percentile

0.6%

Citation Trend

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1016/j.bioorg.2023.106794

publisherhttps://doi.org/10.1016/j.bioorg.2023.106794

publisherhttps://api.elsevier.com/content/article/PII:S0045206823004558?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0045206823004558?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37659146

Fields of Study

Pharmacological Receptor Mechanisms and EffectsHistone Deacetylase Inhibitors ResearchN-Heterocyclic Carbenes in Organic and Inorganic ChemistryHumansLigandsMolecular Docking SimulationDrug Delivery SystemsCell Line, TumorHCT116 Cells

MeSH Terms

HumansLigandsDrug Delivery SystemsHCT116 CellsCell Line, TumorMolecular Docking Simulation

Keywords

ChemistryIC50Docking (animal)In vitroComputational biologyDrug discoveryDrugPharmacologyCell cultureCombinatorial chemistryBiochemistryBiologyGeneticsMedicineCancerΣ(1) ReceptorMultifactorial DiseasesDual-ligandsHdac Enzyme