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Positional isomers of Indolyl-benzodiazepines display dissimilar binding and recruitment of BET transcriptional regulators to targeted genomic loci

Bioorganic Chemistry(2025)10.1016/j.bioorg.2025.108813Source: DataRank Database

Positional isomers of Indolyl-benzodiazepines display dissimilar binding and recruitment of BET transcriptional regulators to targeted genomic loci is a research paper published in Bioorganic Chemistry (2025). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 0.39)OA: greenTopics (35)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (15)

Stanley Nithianantham ORCID,Sudip Dey,Rafi Mohammed,Ashraf Mohammed ORCID,Kelly Churion ORCID

Live enrichment

PubMed:40774106 OpenAlex:https://openalex.org/W4412982675

Office of Emerging Frontiers and Multidisciplinary Activities

Grant: CEE20127

Office of Emerging Frontiers and Multidisciplinary Activities

Grant: CEE 2017079

NIH

Grant: NS108376

NIH

Grant: CA225945

Fulbright Program

Grant: R35GM142772

Fulbright Program

Grant: 2610/F-N APE/2020

United States - India Educational Foundation

Grant: pET28a-BRD2-BD2

NCI NIH HHS

Grant: R01 CA225945

NIGMS NIH HHS

Grant: R01 GM120625

NINDS NIH HHS

Grant: R01 NS108376

FWCI

0.39

Citation Percentile

0.6%

Citation Trend

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12351553/

publisherhttps://api.elsevier.com/content/article/PII:S0045206825006935?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0045206825006935?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bioorg.2025.108813

Fields of Study

Protein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathwaysBenzodiazepinesStructure-Activity RelationshipHumansMolecular StructureIndolesIsomerismMolecular Docking SimulationLigandsTranscription FactorsMolecular Dynamics SimulationDose-Response Relationship, DrugProtein Binding

MeSH Terms

BenzodiazepinesDose-Response Relationship, DrugHumansIndolesIsomerismLigandsProtein BindingStructure-Activity RelationshipTranscription FactorsMolecular StructureMolecular Dynamics SimulationMolecular Docking Simulation

Keywords

ChemistryComputational biologyTranscriptional regulationGeneticsGeneTranscription factorBiochemistryBiology

Sustainable Development Goals

SDG 0: Zero hunger