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Structure-activity relationship studies on 2-thienylidene substituted 3-oxo-2,3-dihydrobenzofuran-7-carboxamides as poly (ADP-ribose) polymerase inhibitors

Bioorganic Chemistry(2025)10.1016/j.bioorg.2025.108941Source: DataRank Database

Structure-activity relationship studies on 2-thienylidene substituted 3-oxo-2,3-dihydrobenzofuran-7-carboxamides as poly (ADP-ribose) polymerase inhibitors is a research paper published in Bioorganic Chemistry (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Enrichment:Funding (8 grants)Impact (FWCI 0.46)OA: greenTopics (32)IDs (PubMed, OpenAlex)

FAIR Checklist

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Ugochi A. Adiele,Griffin Coate,Morgan E. Diolaiti ORCID,Huadong Chen ORCID,Junhao Lu ORCID

Live enrichment

PubMed:40945025 OpenAlex:https://openalex.org/W4414149716

National Institute of General Medical Sciences

Grant: SC3GM131971

Center for Cancer Research

National Institutes of Health

V Foundation

Department of Pharmaceutical Sciences, St. John's University

Institute for Prostate Cancer Research

National Cancer Institute

Gray Foundation

FWCI

0.46

Citation Percentile

0.7%

Citation Trend

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12478838/

publisherhttps://api.elsevier.com/content/article/PII:S0045206825008211?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0045206825008211?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bioorg.2025.108941

Fields of Study

PARP inhibition in cancer therapyCalcium signaling and nucleotide metabolismToxin Mechanisms and ImmunotoxinsStructure-Activity RelationshipPoly(ADP-ribose) Polymerase InhibitorsHumansBenzofuransMolecular StructureDose-Response Relationship, DrugPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerases

MeSH Terms

Poly(ADP-ribose) Polymerase InhibitorsPoly (ADP-Ribose) Polymerase-1BenzofuransDose-Response Relationship, DrugHumansPoly(ADP-ribose) PolymerasesStructure-Activity RelationshipMolecular Structure

Keywords

BenzimidazolePARP1EnzymePolymeraseLead compoundStructure–activity relationshipDockingKnoevenagel CondensationAbc TransportersParylationIn Vitro Adme3-Oxo-2,3-dihydrobenzofuran-7-carboxamideThienylidene