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Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores

Biological Psychiatry(2022)10.1016/j.biopsych.2022.07.014Source: DataRank Database

Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores is a research paper published in Biological Psychiatry (2022). On theSindex it has a DataRank of 0. It has been cited 27 times.

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Open Access27 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (27 grants)Impact (FWCI 4.11)OA: hybridTopics (41)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (15)

Sophie E. Legge ORCID,Leon Hubbard ORCID,Isabella Willcocks ORCID,Kevin S. O’Connell ORCID,Robert L. Smith ORCID

Live enrichment

PubMed:36244804 PMC:PMC10804961 OpenAlex:https://openalex.org/W4289866371

Horizon 2020

Grant: 964874

Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders

Medical Research Council

Grant: MC_PC_17212

Integrating genetic, clinical and phenotypic data to advance stratification, prediction and treatment in mental health.

Medical Research Council

Grant: MR/L010305/1

MRC Centre for Neuropsychiatric Genetics and Genomics

Medical Research Council

Grant: MR/L011794/1

MICA: STRATA - Schizophrenia: Treatment Resistance And Therapeutic Advances

Medical Research Council

Grant: MR/P005748/1

Molecular Genetic Studies of Schizophrenia

Helse Sør-Øst RHF

Grant: 2013-123

Helse Sør-Øst RHF

Grant: 2016097

European Research Council

Grant: 279227

Pharmacogenomic biomarkers as clinical decision making tools for clozapine treatment of schizophrenia

Norges Forskningsråd

Grant: 213837

Genetic influence on brain phenotypes. Implications for disease mechanisms in severe mental disorders

Norges Forskningsråd

Grant: 223273

NORMENT; Norwegian Centre for Mental Disorders Research

Norges Forskningsråd

Grant: 226971

Identifying the polygenic basis of the human brain and psychiatric disorders

Norges Forskningsråd

Grant: 229129

Identifying the polygenic basis of the human brain and neurodevelopmental disorders

National Institutes of Health

Grant: EB00790

National Institutes of Health

Grant: NS057198

Academy of Medical Sciences

Grant: SBF0051083

NIBIB NIH HHS

Grant: R01 EB000790

NINDS NIH HHS

Grant: R01 NS057198

Academy of Medical Sciences

Grant: SBF005\1083

National Institutes of Health

Grant: 5R01NS057198-08

Neuronal, glial and BOLD fMRI signals: From BOLD to 2-photon microscopy

National Institutes of Health

Grant: 5R01EB000790-07

Spatiotemporal Brain Imaging: Microscopic and System Level

National Institutes of Health

Grant: 5K07NS000790-05

IMMUNE SYSTEM ABNORMALITIES IN MULTIPLE SCLEROSIS

Llywodraeth Cymru

Takeda Pharmaceutical Company

European Regional Development Fund

Cardiff University

Seventh Framework Programme

Universitetet i Oslo

FWCI

4.11

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.biologicalpsychiatryjournal.com/article/S0006322322014494/pdf

publisherhttp://www.biologicalpsychiatryjournal.com/article/S0006322322014494/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0006322322014494?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0006322322014494?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.biopsych.2022.07.014

Fields of Study

Genetic Associations and EpidemiologySchizophrenia research and treatmentAdvanced Causal Inference Techniques0301 basic medicine0303 health sciences03 medical and health sciencesHumansClozapineSchizophreniaAntipsychotic AgentsPrescriptionsGenomics

MeSH Terms

ClozapineHumansSchizophreniaAntipsychotic AgentsGenomicsPrescriptions

Keywords

ClozapineSchizophrenia (object-oriented programming)MedicineLogistic regressionInternal medicineTherapeutic drug monitoringPsychiatryCohortOdds ratioCovariatePsychologyDrugStatisticsSchizophreniaPharmacogenomicsGenomicsPrecision MedicinePolygenic Risk ScoresArchival ReportPrescriptions610HumansAntipsychotic Agents

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment

10.6084/m9.figshare.27123680.v1figshare

Additional file 1 of Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment

10.6084/m9.figshare.27123680figshare