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Synthesis and activity of isoleucine sulfonamide derivatives as novel botulinum neurotoxin serotype A light chain inhibitors

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115659Source: DataRank Database

Synthesis and activity of isoleucine sulfonamide derivatives as novel botulinum neurotoxin serotype A light chain inhibitors is a research paper published in Bioorganic & Medicinal Chemistry (2020). On theSindex it has a DataRank of 0.269. It has been cited 5 times.

N/A

0.269DataRank · unranked

Scored on demand from live citation data

Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.25)OA: hybridTopics (30)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.269

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

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Authors (8)

Wendy T. Dao,Alex Ku ORCID,Sandra L. Rodriguez-Beltran,Martin Amezcua ORCID,Alejandra Y. Palomino

Live enrichment

PubMed:32828426 OpenAlex:https://openalex.org/W3044847806

NIGMS NIH HHS

Grant: P41 GM103311

National Institutes of Health

U.S. Department of Defense

National Science Foundation

Allergan Foundation

FWCI

0.25

Citation Percentile

0.6%

Citation Trend

2021

2022

2025

hybridLicense: cc-by

journalhttps://doi.org/10.1016/j.bmc.2020.115659

publisherhttps://doi.org/10.1016/j.bmc.2020.115659

publisherhttps://api.elsevier.com/content/article/PII:S0968089620304892?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0968089620304892?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32828426

Fields of Study

Botulinum Toxin and Related Neurological DisordersCancer Treatment and PharmacologyParkinson's Disease Mechanisms and Treatments

MeSH Terms

Binding SitesClostridium botulinumHumansHydroxamic AcidsIsoleucineProtein BindingProtein ConformationStructure-Activity RelationshipSulfonamidesBotulinum Toxins, Type AMolecular Docking Simulation

Keywords

ChemistryLinkerDocking (animal)Botulinum neurotoxinNeurotoxinStereochemistrySulfonamideBotulismBiochemistryCombinatorial chemistryToxinMicrobiologyAmino acidsBiphenylProtease inhibitorsHydroxamic Acid

Sustainable Development Goals

SDG 0: Good health and well-being