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Targeting NLRP3 signaling by a novel-designed sulfonylurea compound for inhibition of microglial inflammation

Bioorganic & Medicinal Chemistry(2022)10.1016/j.bmc.2022.116645Source: DataRank Database

Targeting NLRP3 signaling by a novel-designed sulfonylurea compound for inhibition of microglial inflammation is a research paper published in Bioorganic & Medicinal Chemistry (2022). On theSindex it has a DataRank of 0. It has been cited 26 times.

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0DataRank · unranked

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Open Access26 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (10 grants)OA: greenTopics (22)IDs (PubMed, PMC)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Ayyiliath M. Sajith ORCID,Xiaotian Xu ORCID,Jianxiong Jiang ORCID,J. Phillip Bowen,Amol A. Kulkarni ORCID

Live enrichment

PubMed:35151118 PMC:PMC8895276

NINDS NIH HHS

Grant: R21 NS109687

National Institute of Neurological Disorders and Stroke

Grant: R01NS105787

NIAID NIH HHS

Grant: P30 AI117970

NIMHD NIH HHS

Grant: U54 MD007597

District of Columbia Developmental Center for AIDS Research

Grant: AI117970

National Institute of Neurological Disorders and Stroke

Grant: R01NS100947

NINDS NIH HHS

Grant: R21 NS133895

Howard University

National Institutes of Health

National Institute of Neurological Disorders and Stroke

green

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8895276

MeSH Terms

MicrogliaCells, CulturedAnimalsMiceInflammationSulfonylurea CompoundsSignal TransductionMolecular StructureStructure-Activity RelationshipDose-Response Relationship, DrugModels, MolecularNLR Family, Pyrin Domain-Containing 3 Protein

Keywords

Molecular mechanicsInflammationMicrogliaQuantum MechanicsComputational ChemistryInflammasomesulfonylureaNlrp3Ams-17Phamacophore Modeling