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Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol

Bioorganic & Medicinal Chemistry(2022)10.1016/j.bmc.2022.117072Source: DataRank Database

Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol is a research paper published in Bioorganic & Medicinal Chemistry (2022). On theSindex it has a DataRank of 0. It has been cited 9 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access9 citations

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doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.63)OA: greenTopics (33)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (12)

Anne‐Marie Ray ORCID,Mckayla Stevens,Emma H. Doud ORCID,Hope Liechty,Alex Washburn ORCID

Live enrichment

PubMed:36356534 PMC:PMC11813185 OpenAlex:https://openalex.org/W4307908388

NCI NIH HHS

Grant: P30 CA082709

NIH HHS

Grant: S10 OD012270

NIGMS NIH HHS

Grant: R01 GM120350

NCATS NIH HHS

Grant: UL1 TR002529

NIDDK NIH HHS

Grant: U54 DK106846

FWCI

0.63

Citation Percentile

0.6%

Citation Trend

2024

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11813185

publisherhttps://api.elsevier.com/content/article/PII:S0968089622004655?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0968089622004655?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bmc.2022.117072

Fields of Study

Heat shock proteins researchEnzyme Structure and Function

MeSH Terms

CytosolHumansMitochondriaColorectal NeoplasmsChaperoninsChaperonin 60Chaperonin 10

Keywords

HSP60CytosolChaperoninCytotoxicityChemistryColorectal cancerCancer researchCancer cellCell biologyCancerBiochemistryHeat shock proteinBiologyIn vitroHsp70Protein foldingEnzymeGeneticsMolecular chaperoneChemotherapeuticsProteostasisHsp10Small Molecule InhibitorsHspd1

Sustainable Development Goals

SDG 0: Good health and well-being