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Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin

Bioorganic & Medicinal Chemistry(2024)10.1016/j.bmc.2024.117614Source: DataRank Database

Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin is a research paper published in Bioorganic & Medicinal Chemistry (2024). On theSindex it has a DataRank of 0. It has been cited 6 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access6 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 0.91)OA: hybridTopics (42)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Arkajyoti Dutta ORCID,Anastasiia M. Tsymbal ORCID,J. McLaughlin ORCID,Yang Chen ORCID,Simon A. Davis ORCID

Live enrichment

PubMed:38340640 PMC:PMC11418912 OpenAlex:https://openalex.org/W4391539494

National Institutes of Health

Grant: AI072425

National Institutes of Health

Grant: S10OD021527

National Institutes of Health

Grant: S10 OD026750

NIAID NIH HHS

Grant: R01 AI072425

NIGMS NIH HHS

Grant: P30 GM124165

National Institutes of Health

Grant: 1S10OD021527-01

Pixel Array Detector for Macromolecular Crystallography

National Institutes of Health

Grant: 3R01AI072425-03S1

Mechanism of cytotoxicity of ricin

National Institutes of Health

Grant: 1S10OD026750-01

A Biacore 8K System

FWCI

0.91

Citation Percentile

0.7%

Citation Trend

2024

2025

2026

hybridLicense: cc-by-nc

journalhttps://doi.org/10.1016/j.bmc.2024.117614

HYBRIDhttps://doi.org/10.1016/j.bmc.2024.117614

publisherhttps://doi.org/10.1016/j.bmc.2024.117614

publisherhttps://api.elsevier.com/content/article/PII:S0968089624000282?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0968089624000282?httpAccept=text/plain

Fields of Study

Toxin Mechanisms and ImmunotoxinsTransgenic Plants and ApplicationsHerbal Medicine Research StudiesMedicineChemistry01 natural sciences0104 chemical sciencesBinding SitesPeptidesProtein BindingRibosomesRicin

MeSH Terms

Binding SitesPeptidesProtein BindingRibosomesRicin

Keywords

RicinChemistryStalkSmall moleculeBinding siteAllosteric regulationBiochemistryToxinPeptideRibosome-inactivating proteinRibosomeEnzymeBiologyRNAFluorescence polarizationRibosome inactivating proteinRicin InhibitorsStructure-based DesignRibosomal P-stalkShiga Toxin InhibitorsBinding SitesPeptidesRibosomesArticleProtein Binding

Sustainable Development Goals

SDG 0: Zero hunger

Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin

FAIR Checklist

Authors (14)

Funding (8 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)