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N-substituted-4-(pyridin-4-ylalkyl)piperazine-1-carboxamides and related compounds as Leishmania CYP51 and CYP5122A1 inhibitors

Bioorganic & Medicinal Chemistry(2024)10.1016/j.bmc.2024.117907Source: DataRank Database

N-substituted-4-(pyridin-4-ylalkyl)piperazine-1-carboxamides and related compounds as Leishmania CYP51 and CYP5122A1 inhibitors is a research paper published in Bioorganic & Medicinal Chemistry (2024). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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Enrichment:Funding (7 grants)Impact (FWCI 1.62)OA: greenTopics (41)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Pankaj Kumar Sharma ORCID,M. Junaid Dar ORCID,Yiru Jin ORCID,Lingli Qin,Anuradha Roy ORCID

Live enrichment

PubMed:39288704 PMC:PMC11552653 OpenAlex:https://openalex.org/W4402306998

National Cancer Institute

Grant: R50-CA243786

University of Michigan Comprehensive Cancer Center

Grant: 2P30-CA016058

National Institute of Allergy and Infectious Diseases

Grant: R01 AI139198

NIGMS NIH HHS

Grant: P20 GM113117

NCI NIH HHS

Grant: P30 CA016058

NCI NIH HHS

Grant: R50 CA243786

National Institutes of Health

FWCI

1.62

Citation Percentile

0.8%

Citation Trend

2024

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11552653/pdf/nihms-2024323.pdf

GREENhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11552653/pdf/nihms-2024323.pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11552653/pdf/nihms-2024323.pdf

publisherhttps://api.elsevier.com/content/article/PII:S0968089624003213?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0968089624003213?httpAccept=text/plain

Fields of Study

Research on Leishmaniasis StudiesTrypanosoma species research and implicationsSynthesis and Biological EvaluationMedicineChemistryPiperazinesStructure-Activity RelationshipLeishmania donovaniAntiprotozoal AgentsMolecular StructureSterol 14-DemethylaseAnimalsCytochrome P-450 Enzyme InhibitorsHumans14-alpha Demethylase Inhibitors

MeSH Terms

AnimalsAntiprotozoal AgentsHumansLeishmania donovaniPiperazinesStructure-Activity RelationshipMolecular StructureSterol 14-Demethylase14-alpha Demethylase InhibitorsCytochrome P-450 Enzyme Inhibitors

Keywords

PiperazineChemistryCarboxamideLeishmania donovaniStereochemistryAmastigoteGrowth inhibitionEnzymeLeishmaniaIn vitroBiochemistryOrganic chemistryLeishmaniasisdrug discoveryCyp51Cyp5122a1

Sustainable Development Goals

SDG 0: Zero hunger

N-substituted-4-(pyridin-4-ylalkyl)piperazine-1-carboxamides and related compounds as Leishmania CYP51 and CYP5122A1 inhibitors

FAIR Checklist

Authors (16)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)