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Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128058Source: DataRank Database

Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors is a research paper published in Bioorganic & Medicinal Chemistry Letters (2021). On theSindex it has a DataRank of 0. It has been cited 16 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access16 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 1.09)OA: hybridTopics (44)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (28)

David Surguladze,An‐Hu Li ORCID,Matthew D. Surman,Srikanth Malibhatla,Madhavarao Bandaru

Live enrichment

PubMed:33895276 OpenAlex:https://openalex.org/W3158460264

National Institute of General Medical Sciences

Grant: AGM-12006

National Institutes of Health

Grant: ACB-12002

Argonne National Laboratory

Grant: DE-AC02-06CH11357

National Cancer Institute

Office of Science

U.S. Department of Energy

FWCI

1.09

Citation Percentile

0.7%

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1016/j.bmcl.2021.128058

publisherhttps://doi.org/10.1016/j.bmcl.2021.128058

publisherhttps://api.elsevier.com/content/article/PII:S0960894X21002845?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0960894X21002845?httpAccept=text/plain

repositoryhttps://pubmed.ncbi.nlm.nih.gov/33895276

Fields of Study

Endoplasmic Reticulum Stress and DiseaseCellular transport and secretionAutophagy in Disease and TherapyAdministration, OralBiological AvailabilityDose-Response Relationship, DrugDrug DiscoveryHumansMolecular StructurePyridinesStructure-Activity RelationshipeIF-2 Kinase

MeSH Terms

Administration, OralBiological AvailabilityDose-Response Relationship, DrugHumansPyridinesStructure-Activity RelationshipMolecular StructureeIF-2 KinaseDrug Discovery

Keywords

Endoplasmic reticulumProtein kinase RUnfolded protein responseBioavailabilityKinaseProtein kinase AChemistryPharmacologyCarcinogenesisCellCancer researchBiochemistryMedicineMitogen-activated protein kinase kinaseGeneCancerInhibitorefficacypERKUprOrally Bioavailable786-O CellStructure–activity-relationships (Sar)

Sustainable Development Goals

SDG 0: Good health and well-being