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Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128171Source: DataRank Database

Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore is a research paper published in Bioorganic & Medicinal Chemistry Letters (2021). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Enrichment:Funding (2 grants)Impact (FWCI 0.76)OA: greenTopics (40)IDs (PubMed, PMC, OpenAlex)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Janice A. Sindac ORCID,Craig J. Dobry ORCID,Philip C. Delekta,Pil H. Lee ORCID,David J. Miller ORCID

Live enrichment

PubMed:34098081 PMC:PMC8272561 OpenAlex:https://openalex.org/W3166747996

NIAID NIH HHS

Grant: R01 AI089417

National Institutes of Health

FWCI

0.76

Citation Percentile

0.7%

Citation Trend

2023

2024

2025

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8272561

publisherhttps://api.elsevier.com/content/article/PII:S0960894X2100398X?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0960894X2100398X?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bmcl.2021.128171

Fields of Study

Mosquito-borne diseases and controlHIV Research and TreatmentVirology and Viral DiseasesAlphavirusAntiviral AgentsDose-Response Relationship, DrugDrug DesignIndolesMicrobial Sensitivity TestsMolecular ConformationStructure-Activity RelationshipVirus Replication

MeSH Terms

AlphavirusAntiviral AgentsDose-Response Relationship, DrugIndolesMicrobial Sensitivity TestsMolecular ConformationStructure-Activity RelationshipVirus ReplicationDrug Design

Keywords

PharmacophoreChemistryAlphavirusIndole testVirtual screeningStereochemistryPotencyCombinatorial chemistryChemical synthesisComputational biologyBiochemistryIn vitroVirologyVirusBiologyWestern equine encephalitis virusAntiviralConformationally RestrictedNeurotropic Alphavirus