Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Design, synthesis, and biological evaluation of polyphenol derivatives as DYRK1A inhibitors. The discovery of a potentially promising treatment for Multiple Sclerosis

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.128675Source: DataRank Database

Design, synthesis, and biological evaluation of polyphenol derivatives as DYRK1A inhibitors. The discovery of a potentially promising treatment for Multiple Sclerosis is a research paper published in Bioorganic & Medicinal Chemistry Letters (2022). On theSindex it has a DataRank of 0. It has been cited 12 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access12 citations

Download PDF

Cite:

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 0.78)OA: greenTopics (45)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

Authors (2)

Yu‐Wen Hwang ORCID,Gian Luca Araldi ORCID

Live enrichment

PubMed:35292341 PMC:PMC9067539 OpenAlex:https://openalex.org/W4220890344

National Institute on Aging

Grant: 1R43AG063560-01

DYRK1A inhibitors as therapeutic approach to Tau hyper-phosphorylation for treatment of Alzheimer disease and other CNS disorders

NIA NIH HHS

Grant: R44 AG056181

NIA NIH HHS

Grant: R43 AG063560

National Institutes of Health

FWCI

0.78

Citation Percentile

0.7%

Citation Trend

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9067539

publisherhttps://api.elsevier.com/content/article/PII:S0960894X22001512?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0960894X22001512?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bmcl.2022.128675

Fields of Study

Protein Tyrosine PhosphatasesTryptophan and brain disorders14-3-3 protein interactions0301 basic medicine0303 health sciences03 medical and health sciencesCatechinHumansMultiple SclerosisPhosphorylationPolyphenolsStructure-Activity RelationshipTea

MeSH Terms

CatechinHumansMultiple SclerosisPhosphorylationStructure-Activity RelationshipTeaPolyphenols

Keywords

ChemistryCatechinPolyphenolDYRK1ABiological activityIn vivoStructure–activity relationshipEpigallocatechin gallateGallatePhosphorylationIC50BiochemistryIn vitroDerivative (finance)Chemical synthesisStereochemistryCombinatorial chemistryAntioxidantPolyphenolsMultiple sclerosisEGCGEAEStructure-Activity RelationshipTeaHumans

Sustainable Development Goals

SDG 3: 3. Good health