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A virtual screening strategy to repurpose antifolate compounds as W. bancrofti DHFR inhibitors

Bioorganic & Medicinal Chemistry Letters(2025)10.1016/j.bmcl.2025.130370Source: DataRank Database

A virtual screening strategy to repurpose antifolate compounds as W. bancrofti DHFR inhibitors is a research paper published in Bioorganic & Medicinal Chemistry Letters (2025). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)Impact (FWCI 0.00)OA: greenTopics (56)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Jacquelyn Wilhelm,Merna Salama,Monika Salama,Klarissa Hollander ORCID,Karen S. Anderson ORCID

Live enrichment

PubMed:40812516 OpenAlex:https://openalex.org/W4413139965

NIH National Institute of General Medical Sciences

Grant: P30GM133893

National Science Foundation

Grant: 2030879

Increasing Access to Graduate Degrees, Professional Development, and Research Experiences: Pathways to Achievement in Chemical Industries

Brookhaven National Laboratory

Grant: DE-SC0012704

Biological and Environmental Research

Grant: KP1605010

FWCI

0.00

Citation Percentile

0.2%

greenLicense: Elsevier TDM

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12477653/

publisherhttps://api.elsevier.com/content/article/PII:S0960894X25002793?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0960894X25002793?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bmcl.2025.130370

Fields of Study

Trypanosoma species research and implicationsStudies on Chitinases and ChitosanasesParasitic Diseases Research and Treatment01 natural sciences0104 chemical sciencesFolic Acid AntagonistsTetrahydrofolate DehydrogenaseStructure-Activity RelationshipMolecular Docking SimulationMolecular StructureBinding SitesAnimalsMethotrexateDrug Evaluation, PreclinicalHumansDose-Response Relationship, Drug

MeSH Terms

AnimalsBinding SitesDose-Response Relationship, DrugDrug Evaluation, PreclinicalFolic Acid AntagonistsHumansMethotrexateStructure-Activity RelationshipTetrahydrofolate DehydrogenaseMolecular StructureMolecular Docking Simulation

Keywords

Dihydrofolate reductaseAntifolateChemistryVirtual screeningWuchereria bancroftiMethotrexateEnzymeBiochemistryPharmacologyDrug discoveryAntimetaboliteBiologyFilariasisToxicityImmunologyBinding SitesMolecular StructureDose-Response Relationship, DrugDrug Evaluation, PreclinicalArticleMolecular Docking SimulationTetrahydrofolate DehydrogenaseStructure-Activity RelationshipFolic Acid AntagonistsAnimalsHumansAntifolate compoundsCrystal structuresLymphatic filariasis

Sustainable Development Goals

SDG 0: Good health and well-being