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Design, synthesis, and anticancer evaluation of benzimidazole and benzothiazole derivatives targeting Hsp70 and FoxM1

Bioorganic & Medicinal Chemistry Letters(2025)10.1016/j.bmcl.2025.130401Source: DataRank Database

Design, synthesis, and anticancer evaluation of benzimidazole and benzothiazole derivatives targeting Hsp70 and FoxM1 is a research paper published in Bioorganic & Medicinal Chemistry Letters (2025). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.00)OA: greenTopics (49)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Khosrow Kashfi ORCID,Maryam Abbasi ORCID,Ghadamali Khodarahmi ORCID,Zahra Alimardan

Live enrichment

PubMed:40939706 OpenAlex:https://openalex.org/W4414106808

National Institutes of Health

Grant: R01GM123508

National Institute on Minority Health and Health Disparities

Grant: 2U54MD017979-01A1

Iran National Science Foundation

Grant: 97006190

Isfahan University of Medical Sciences

Grant: 140162

NIMHD NIH HHS

Grant: U54 MD017979

FWCI

0.00

Citation Percentile

0.1%

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12491069/

publisherhttps://api.elsevier.com/content/article/PII:S0960894X25003105?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0960894X25003105?httpAccept=text/plain

journalhttps://www.sciencedirect.com/science/article/pii/S0960894X25003105/pdf

Fields of Study

Heat shock proteins researchFOXO transcription factor regulationMedicineChemistryHumansBenzimidazolesBenzothiazolesAntineoplastic AgentsDrug DesignHSP70 Heat-Shock ProteinsForkhead Box Protein M1Molecular Docking SimulationStructure-Activity RelationshipDrug Screening Assays, AntitumorForkhead Transcription FactorsCell ProliferationMCF-7 CellsHeLa CellsMolecular StructureBinding Sites

MeSH Terms

Forkhead Box Protein M1Antineoplastic AgentsBenzimidazolesBinding SitesDrug Screening Assays, AntitumorHeLa CellsHumansStructure-Activity RelationshipDrug DesignMolecular StructureHSP70 Heat-Shock ProteinsCell ProliferationForkhead Transcription FactorsBenzothiazolesMCF-7 CellsMolecular Docking SimulationHela Cells

Keywords

BenzothiazoleBenzimidazoleDocking (animal)CytotoxicityMTT assayLigand binding assayStructure–activity relationshipBinding affinitiesCancer therapyHSP70Molecular dockingFoxm1