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Synthesis of novel 6-azacytidine prodrugs as potent influenza A inhibitors

Bioorganic & Medicinal Chemistry Letters(2025)10.1016/j.bmcl.2025.130473Source: DataRank Database

Synthesis of novel 6-azacytidine prodrugs as potent influenza A inhibitors is a research paper published in Bioorganic & Medicinal Chemistry Letters (2025). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 0.00)OA: greenTopics (65)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Larry Bratton,Shuklendu D. Karyakarte ORCID,Kathy A. Keith ORCID,Yohanka Martinez-Gzegozewska ORCID,Sarath C. Sarngadharan

Live enrichment

PubMed:41242348 OpenAlex:https://openalex.org/W4416373484

National Institutes of Health

Grant: 1U19AI109680-01

Medicinal Chemistry and Lead Development Core

National Institutes of Health

Grant: 1U19AI142759-01

Antiviral Drug Discovery and Development Center (AD3C)

NIAID NIH HHS

Grant: U19 AI109680

NIAID NIH HHS

Grant: U19 AI142759

FWCI

0.00

Citation Percentile

0.4%

greenLicense: Elsevier TDM

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13196463/

publisherhttps://api.elsevier.com/content/article/PII:S0960894X25003828?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0960894X25003828?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bmcl.2025.130473

Fields of Study

Influenza Virus Research StudiesHIV/AIDS drug development and treatmentClick Chemistry and Applications01 natural sciences0104 chemical sciencesProdrugsAntiviral AgentsHumansAnimalsDogsMiceStructure-Activity RelationshipMadin Darby Canine Kidney CellsAzacitidineInfluenza A Virus, H1N1 SubtypeMolecular StructureInfluenza A Virus, H3N2 SubtypeMicrobial Sensitivity TestsInfluenza A virusDose-Response Relationship, DrugMicrosomes, Liver

MeSH Terms

AnimalsAntiviral AgentsAzacitidineDogsDose-Response Relationship, DrugHumansMicrobial Sensitivity TestsMicrosomes, LiverInfluenza A virusProdrugsStructure-Activity RelationshipMolecular StructureMiceInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeMadin Darby Canine Kidney Cells

Keywords

ProdrugMicrosomeNucleosideCytotoxicityPharmacokineticsBioavailabilityPotencyChemical synthesisIn vivoMolecular StructureDose-Response Relationship, DrugInfluenza A Virus, H3N2 SubtypeMicrobial Sensitivity TestsAntiviral AgentsMadin Darby Canine Kidney CellsMiceStructure-Activity RelationshipDogsInfluenza A Virus, H1N1 SubtypeInfluenza A virusAzacitidineMicrosomes, LiverHumansAnimalsProdrugs6-AzacytidineInfluenza A inhibitionNucleoside prodrug approach