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Conformational dynamics of the membrane enzyme LspA upon antibiotic and substrate binding

Biophysical Journal(2022)10.1016/j.bpj.2022.04.038Source: DataRank Database

Conformational dynamics of the membrane enzyme LspA upon antibiotic and substrate binding is a research paper published in Biophysical Journal (2022). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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Enrichment:Funding (44 grants)Impact (FWCI 0.55)OA: bronzeTopics (48)IDs (PubMed, PMC, OpenAlex)Annotations (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Owen N. Vickery ORCID,Jonathan D. Colburn ORCID,Phillip J. Stansfeld ORCID,Linda Columbus ORCID,Tracy A. Caldwell ORCID

Live enrichment

PubMed:35505611 PMC:PMC9247476 OpenAlex:https://openalex.org/W4225291781

Wellcome Trust

Grant: 208361/Z/17/Z

Virginia Marine Resources Commission

Grant: MR/S009213/1

Triggering assembly of the twin-arginine translocase

EPSRC

Grant: EP/L000253/1

The UK High-End Computing Consortium for Biomolecular Simulation

EPSRC

Grant: EP/P020232/1

Proposal for a Tier 2 Centre - HPC Midlands Plus

National Institutes of Health

Grant: R35 GM13182

National Institutes of Health

Grant: 5T32GM080186\u201307

BBSRC

Grant: BB/R002517/1

Functional dynamics of the KATP channel

BBSRC

Grant: BB/P01948X/1

The Lipoprotein Biogenesis Pathway: An Emerging Structural Target for Novel Antibiotics

BBSRC

Grant: BB/S003339/1

Assembly and Dynamics of Bacterial Chemosensory Signaling Arrays

National Science Foundation

Grant: MCB1817735

Biotechnology and Biological Sciences Research Council

Grant: BB/P01948X/2

Engineering and Physical Sciences Research Council

Grant: EP/J010588/1

Engineering and Physical Sciences Research Council

Grant: EP/M027546/1

Engineering and Physical Sciences Research Council

Grant: EP/W013738/1

NIGMS NIH HHS

Grant: R35 GM131821

National Institutes of Health

Grant: 5T32GM080186–07

Biotechnology and Biological Sciences Research Council

Grant: BB/L018756/1

Engineering and Physical Sciences Research Council

Grant: EP/G007705/1

NIGMS NIH HHS

Grant: T32 GM080186

Biotechnology and Biological Sciences Research Council

Grant: BB/K016601/1

Engineering and Physical Sciences Research Council

Grant: EP/G042853/1

Engineering and Physical Sciences Research Council

Grant: EP/N024117/1

Engineering and Physical Sciences Research Council

Grant: EP/I030395/1

Engineering and Physical Sciences Research Council

Grant: EP/R029407/1

Engineering and Physical Sciences Research Council

Grant: EP/R029407/2

NIH HHS

Grant: S10 OD025149

Biotechnology and Biological Sciences Research Council

Grant: 1274908

Biotechnology and Biological Sciences Research Council

Grant: BB/T017066/1

Engineering and Physical Sciences Research Council

Grant: EP/E022197/1

Engineering and Physical Sciences Research Council

Grant: GR/R86119/01

NIGMS NIH HHS

Grant: R35 GM131829

Biotechnology and Biological Sciences Research Council

Grant: BB/V016768/1

Biotechnology and Biological Sciences Research Council

Grant: BB/L01386X/1

Engineering and Physical Sciences Research Council

Grant: EP/M022609/1

Engineering and Physical Sciences Research Council

Grant: EP/G002843/1

Engineering and Physical Sciences Research Council

Grant: EP/M015378/1

National Institutes of Health

Grant: 5T32GM080186-07

Training in Molecular Biophysics

National Institutes of Health

Grant: 1F32GM013182-01

ANALYSIS OF BETA-ADRENERGIC RECEPTOR DESENSITIZATION

National Science Foundation

Grant: 1817735

Investigating the impact of lipid-protein interactions in membrane protein structure and conformational dynamics

Wellcome Trust

Grant: 208361

LipID: A Lipid Annotation Tool for Membrane Proteins

University of Warwick

Virginia Marine Resources Commission

Wellcome Trust

FWCI

0.55

Citation Percentile

0.6%

Citation Trend

2022

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttp://www.cell.com/article/S0006349522003666/pdf

publisherhttp://www.cell.com/article/S0006349522003666/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0006349522003666?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0006349522003666?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.bpj.2022.04.038

Fields of Study

Protein Structure and DynamicsStreptococcal Infections and TreatmentsRNA and protein synthesis mechanisms0301 basic medicine0303 health sciences03 medical and health sciencesAnti-Bacterial AgentsAspartic Acid EndopeptidasesBacterial ProteinsCatalytic DomainLipoproteinsMolecular Dynamics SimulationProtein Conformation

MeSH Terms

Anti-Bacterial AgentsBacterial ProteinsLipoproteinsProtein ConformationAspartic Acid EndopeptidasesCatalytic DomainMolecular Dynamics Simulation

Keywords

Periplasmic spaceLipid bilayerHelix (gastropod)Bacterial outer membraneTransmembrane proteinActive siteBiologyProteaseBiophysicsProtein structureTransmembrane domainBinding siteBiochemistryEnzymeCrystallographyChemistryMembraneReceptorTPBacterial ProteinsProtein ConformationQHCatalytic DomainLipoproteinsAspartic Acid EndopeptidasesMolecular Dynamics SimulationQPAnti-Bacterial Agents

Conformational dynamics of the membrane enzyme LspA upon antibiotic and substrate binding

FAIR Checklist

Authors (5)

Funding (44 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)