Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

Targeting UHRF1-dependent DNA repair selectively sensitizes KRAS mutant lung cancer to chemotherapy

Cancer Letters(2020)10.1016/j.canlet.2020.08.008Source: DataRank Database

Targeting UHRF1-dependent DNA repair selectively sensitizes KRAS mutant lung cancer to chemotherapy is a research paper published in Cancer Letters (2020). On theSindex it has a DataRank of 0.533. It has been cited 34 times.

N/A

0.533DataRank · unranked

Scored on demand from live citation data

Open Access34 citations

Free full text

Cite:

Linked data & code

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 1.04)OA: greenTopics (86)Linked Datasets (5)DataCite Reuse (5)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.533

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

This paper's DataRank is currently driven only by its base citation score. Citation network data was not refreshed for this result.

Learn more about DataRank methodology →

Authors (9)

Jinshan Tang ORCID,Xinran Geng ORCID,Qingwen Li ORCID,Fangfang Wang ORCID,Huadong Zhao

Live enrichment

PubMed:32814087 OpenAlex:https://openalex.org/W3049530820

National Institutes of Health

Grant: R01CA230453

American Cancer Society

Grant: ACS RSG-15-042 DMC

National Natural Science Foundation of China

Grant: 81673320

National Natural Science Foundation of China

Grant: 81728022

National Natural Science Foundation of China

Grant: 81903482

National Institutes of Health

Grant: 5R01CA230453-05

Targeting DNA repair in KRAS mutated lung cancer by chemical screening

NCI NIH HHS

Grant: R01 CA181654

NCI NIH HHS

Grant: R01 CA240993

FWCI

1.04

Citation Percentile

0.8%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: Elsevier TDM

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8293908

publisherhttps://api.elsevier.com/content/article/PII:S0304383520304213?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0304383520304213?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.canlet.2020.08.008

Fields of Study

DNA Repair MechanismsRNA modifications and cancerUbiquitin and proteasome pathways0301 basic medicine0303 health sciences03 medical and health sciencesA549 CellsAnimalsCCAAT-Enhancer-Binding ProteinsCardiac GlycosidesCell Line, TumorDNA RepairDown-RegulationDrug Screening Assays, AntitumorDrug SynergismDrug TherapyFemaleGene Expression Regulation, NeoplasticHumansLung NeoplasmsMass SpectrometryMiceMutationProto-Oncogene Proteins p21(ras)Ubiquitin-Protein LigasesXenograft Model Antitumor Assays

MeSH Terms

A549 CellsAnimalsCardiac GlycosidesDNA RepairDrug Screening Assays, AntitumorDrug SynergismDrug TherapyFemaleHumansLung NeoplasmsMutationMass SpectrometryDown-RegulationGene Expression Regulation, NeoplasticProto-Oncogene Proteins p21(ras)CCAAT-Enhancer-Binding ProteinsXenograft Model Antitumor AssaysUbiquitin-Protein LigasesCell Line, TumorMice

Keywords

KRASLung cancerCancer researchBiologyChemotherapyCancerMutantMedicineInternal medicineBiochemistryGeneColorectal cancerGeneticsLung NeoplasmsDNA RepairUbiquitin-Protein LigasesDown-RegulationDrug SynergismXenograft Model Antitumor AssaysMass SpectrometryCardiac GlycosidesGene Expression Regulation, NeoplasticProto-Oncogene Proteins p21(ras)MiceDrug TherapyA549 CellsCell Line, TumorMutationCCAAT-Enhancer-Binding ProteinsAnimalsHumansFemaleDrug Screening Assays, AntitumorCardiac glycosideChemo sensitizerCompound library screenDNA damage ResponseDSB repairKRAS mutationUHRF1

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of STUB1-mediated K63-linked ubiquitination of UHRF1 promotes the progression of cholangiocarcinoma by maintaining DNA hypermethylation of PLA2G2A

10.6084/m9.figshare.27012226.v1figshare

Additional file 2 of STUB1-mediated K63-linked ubiquitination of UHRF1 promotes the progression of cholangiocarcinoma by maintaining DNA hypermethylation of PLA2G2A

10.6084/m9.figshare.27012232.v1figshare

Additional file 4 of STUB1-mediated K63-linked ubiquitination of UHRF1 promotes the progression of cholangiocarcinoma by maintaining DNA hypermethylation of PLA2G2A

10.6084/m9.figshare.27012238.v1figshare

Additional file 5 of STUB1-mediated K63-linked ubiquitination of UHRF1 promotes the progression of cholangiocarcinoma by maintaining DNA hypermethylation of PLA2G2A

10.6084/m9.figshare.27012244.v1figshare

Additional file 3 of STUB1-mediated K63-linked ubiquitination of UHRF1 promotes the progression of cholangiocarcinoma by maintaining DNA hypermethylation of PLA2G2A

10.6084/m9.figshare.27012235.v1figshare