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Restricting metabolic plasticity enhances stress adaptation through the modulation of PDH and HIF1A in TRAP1-depleted colon cancer

Cancer Letters(2025)10.1016/j.canlet.2025.217977Source: DataRank Database

Restricting metabolic plasticity enhances stress adaptation through the modulation of PDH and HIF1A in TRAP1-depleted colon cancer is a research paper published in Cancer Letters (2025). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Enrichment:Funding (4 grants)OA: hybridTopics (23)IDs (PubMed, PMC)

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Authors (9)

Miao-Hsueh Chen ORCID,Ji-Hye Yun ORCID,Lisa A. Lai,John F. Valentine ORCID,Mary P. Bronner ORCID

Live enrichment

PubMed:40789509 PMC:PMC12582411

NIH NCI

Grant: R01CA276173

NIH NCI

Grant: R01CA211892

NIDDK NIH HHS

Grant: P30 DK056338

National Institutes of Health

hybridLicense: cc-by-nc

publisherhttps://doi.org/10.1016/j.canlet.2025.217977

publisherhttps://api.elsevier.com/content/article/PII:S0304383525005476?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0304383525005476?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12582411

Europe_PMChttps://europepmc.org/articles/PMC12582411

MeSH Terms

Cell Line, TumorHCT116 CellsHumansColonic NeoplasmsReactive Oxygen SpeciesMonocarboxylic Acid TransportersSymportersAdaptation, PhysiologicalGene Expression Regulation, NeoplasticOxidative PhosphorylationGlycolysisHSP90 Heat-Shock ProteinsGlucose Transporter Type 1Hypoxia-Inducible Factor 1, alpha SubunitCRISPR-Cas SystemsPyruvate Dehydrogenase Acetyl-Transferring KinaseMonocarboxylate Transport Protein 1

Keywords

MitochondriaMetabolismROSPdhTrap1Hif1a