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Cancer-associated fibroblast secreted DKK1 promotes the immunosuppressive tumor microenvironment and colorectal cancer resistance to chemotherapy

Cancer Letters(2025)10.1016/j.canlet.2025.218060Source: DataRank Database

Cancer-associated fibroblast secreted DKK1 promotes the immunosuppressive tumor microenvironment and colorectal cancer resistance to chemotherapy is a research paper published in Cancer Letters (2025). On theSindex it has a DataRank of 0.312. It has been cited 7 times.

N/A

0.312DataRank · unranked

Scored on demand from live citation data

Open Access7 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 4.18)OA: hybridTopics (44)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.312

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (8)

Yuning Zhou ORCID,Xudong Zhu ORCID,Ryan Goettl,Chi Wang ORCID,Heidi L. Weiss

Live enrichment

PubMed:41005453 OpenAlex:https://openalex.org/W4414579191

National Cancer Institute Division of Cancer Prevention

Grant: P30 CA177558

National Cancer Institute Division of Cancer Prevention

Grant: R01 CA272669

National Institutes of Health

Grant: R01 DK48498

National Cancer Institute

Markey Cancer Center, University of Kentucky

FWCI

4.18

Citation Percentile

1.0%

Influential Citations

Citation Trend

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1016/j.canlet.2025.218060

HYBRIDhttps://doi.org/10.1016/j.canlet.2025.218060

publisherhttps://doi.org/10.1016/j.canlet.2025.218060

publisherhttps://api.elsevier.com/content/article/PII:S0304383525006329?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0304383525006329?httpAccept=text/plain

Fields of Study

Peptidase Inhibition and AnalysisCancer, Hypoxia, and MetabolismNeuroendocrine Tumor Research AdvancesMedicineBiologyHumansColorectal NeoplasmsTumor MicroenvironmentCancer-Associated FibroblastsIntercellular Signaling Peptides and ProteinsDrug Resistance, NeoplasmAnimalsFluorouracilMiceCell Line, TumorFemaleXenograft Model Antitumor AssaysIrinotecanOxaliplatinMale

MeSH Terms

Cancer-Associated FibroblastsIrinotecanOxaliplatinAnimalsFemaleFluorouracilHumansMaleColorectal NeoplasmsDrug Resistance, NeoplasmXenograft Model Antitumor AssaysIntercellular Signaling Peptides and ProteinsCell Line, TumorMiceTumor Microenvironment

Keywords

ChemotherapyDKK1Colorectal cancerTumor microenvironmentIn vivoDownregulation and upregulationGene knockdownCancerCancer-associated Fibroblasts