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KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer

Cancer Cell(2020)10.1016/j.ccell.2020.03.005Source: DataRank Database

KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer is a research paper published in Cancer Cell (2020). On theSindex it has a DataRank of 0. It has been cited 248 times.

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Open Access248 citations

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Enrichment:Funding (24 grants)Impact (FWCI 13.83)OA: bronzeTopics (98)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (19)

Ming Tang ORCID,Mayinuer Maitituoheti ORCID,Shilpa S. Dhar,Manish Kumar ORCID,Chae Young Han ORCID

Live enrichment

PubMed:32243837 PMC:PMC7178078 OpenAlex:https://openalex.org/W3014830213

University of Texas MD Anderson Cancer Center

Grant: R00CA160578

National Cancer Institute

Grant: P30CA016672

American Cancer Society

Grant: RSG-15-145-01-CDD

National Institutes of Health

Grant: R01CA207109

National Institutes of Health

Grant: R01CA157919

National Institutes of Health

Grant: R01CA207098

National Institute of Environmental Health Sciences

Grant: Z1AES103311-10

National Institute of Environmental Health Sciences

Grant: R35CA197452

Cancer Prevention and Research Institute of Texas

Grant: RP170005

Cancer Prevention and Research Institute of Texas

Grant: 127430-RSG-15-105-01-CNE

NCI NIH HHS

Grant: R01 CA216426

NCI NIH HHS

Grant: R01 CA220297

NCI NIH HHS

Grant: K99 CA160578

NCI NIH HHS

Grant: R01 CA222214

NHLBI NIH HHS

Grant: R01 HL130129

National Institutes of Health

Grant: 5R01CA157919-02

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National Institutes of Health

Grant: 1K99CA160578-01

Epigenetics of Melanoma Metastasis

National Institutes of Health

Grant: 1R01CA207098-01A1

Role of the Histone Modifier KDM2A in Lung Cancer

National Institutes of Health

Grant: 5R01CA216426-05

Identify the DNA Adduct and Associated Metabolic Alterations in Bladder Cancer of Smokers

National Institutes of Health

Grant: 3P30CA016672-41S4

Cancer Center Support (CORE) Grant

National Institutes of Health

Grant: 5R01CA207109-04

Role of the Histone Methyltransferase MLL4 in Medulloblastoma

National Institutes of Health

Grant: 5R01CA220297-02

Racial Disparity in Bladder Cancer and Identification of Altered Metabolism in African American Compare to European Bladder Cancer

National Institutes of Health

Grant: 5R35CA197452-04

Identification of non-coding RNAs to therapeutically target undruggable pathways in metastatic lung adenocarcinoma and squamous cell carcinoma

National Institutes of Health

Grant: 1ZIAES103311-06

Environmental Signaling in Reproduction and Pregnancy

FWCI

13.83

Citation Percentile

1.0%

Citation Trend

2020

2021

2022

2023

2024

2025

2026

bronzeLicense: Elsevier Non-Commercial

journalhttp://www.cell.com/article/S1535610820301069/pdf

publisherhttp://www.cell.com/article/S1535610820301069/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1535610820301069?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1535610820301069?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ccell.2020.03.005

Fields of Study

Epigenetics and DNA MethylationRNA modifications and cancerCancer-related gene regulation0301 basic medicine0303 health sciences03 medical and health sciencesAdenocarcinoma of LungAnimalsAntimetabolitesApoptosisBiomarkers, TumorCell ProliferationDNA-Binding ProteinsDeoxyglucoseEnhancer Elements, GeneticGene Expression Regulation, NeoplasticGlycolysisHistone-Lysine N-MethyltransferaseHistonesHumansLung NeoplasmsMiceMice, KnockoutMice, NudeMutationMyeloid-Lymphoid Leukemia ProteinNeoplasm ProteinsPeriod Circadian ProteinsPrognosisTumor Cells, CulturedXenograft Model Antitumor Assays

MeSH Terms

Adenocarcinoma of LungAnimalsAntimetabolitesDeoxyglucoseDNA-Binding ProteinsEnhancer Elements, GeneticGlycolysisHistonesHumansLung NeoplasmsMice, NudeMutationNeoplasm ProteinsPrognosisHistone-Lysine N-MethyltransferaseTumor Cells, CulturedBiomarkers, TumorGene Expression Regulation, NeoplasticApoptosisMice, KnockoutXenograft Model Antitumor AssaysCell ProliferationMiceMyeloid-Lymphoid Leukemia ProteinPeriod Circadian Proteins

Keywords

BiologyCancer researchCarcinogenesisEnhancerEpigeneticsLung cancerEpigenomicsCancerGeneticsGeneGene expressionDNA methylationMedicinePathologyMetabolismInhibitorTumor suppressorhistone methyltransferasehistone methylationglycolysisEpigenetic ModifierKmt2dSuper-enhancerMice, KnockoutLung NeoplasmsAntimetabolitesMice, NudeAdenocarcinoma of LungApoptosisHistone-Lysine N-MethyltransferaseDeoxyglucoseDNA-Binding ProteinsGene Expression Regulation, NeoplasticHistonesMiceEnhancer Elements, GeneticMutationBiomarkers, TumorAnimalsHumansMyeloid-Lymphoid Leukemia ProteinCell Proliferation

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer

FAIR Checklist

Authors (19)

Funding (24 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)