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Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

Cancer Cell(2020)10.1016/j.ccell.2020.05.010Source: DataRank Database

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer is a research paper published in Cancer Cell (2020). On theSindex it has a DataRank of 4.8. It has been cited 164 times, with 150 citing works in its 1-hop citation network.

N/A

4.8DataRank · unranked

Scored on demand from live citation data

Open Access164 citations · 150 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (17 grants)OA: bronzeTopics (65)IDs (PubMed)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 16%Citation Network 84%

Base Score Contribution

0.766

From this paper's citation signal

Citation Network Contribution

4.0

From 123 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 150 citers.

RBFOX2: a key factor in suppressing PDAC metastasis through regulation of alternative splicing events
Signal Transduction and Targeted Therapy20232 citations5 referencesContributes 0.220
Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia
Proceedings of the National Academy of Sciences202146 citations30 referencesContributes 0.128
Novel Approach to Enriching Glycosylated RNAs: Specific Capture of GlycoRNAs via Solid-Phase Chemistry
Analytical Chemistry202347 citations31 referencesContributes 0.125
KRAS mutations as essential promoters of lymphangiogenesis via extracellular vesicles in pancreatic cancer
Journal of Clinical Investigation202216 citations23 referencesContributes 0.123
Identification of mutant p53-specific proteins interaction network using TurboID-based proximity labeling
Biochemical and Biophysical Research Communications202217 citations28 referencesContributes 0.103

Authors (44)

Alex Penson,Ram Kannan,Hana Cho ORCID,Chun‐Hao Pan ORCID,Rohit K. Singh ORCID

Live enrichment

PubMed:32559497

National Cancer Institute

Grant: K99 CA226342 01

International Monetary Fund

Grant: OE121701

National Heart, Lung, and Blood Institute

Grant: R01 HL128239

National Institutes of Health

Grant: P30 CA023108

National Institutes of Health

Grant: R01 CA204228-01

Deutsche Forschungsgemeinschaft

Grant: OE531/2-2

Deutsche Forschungsgemeinschaft

Grant: KU2531/2

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

NCI NIH HHS

Grant: R35 CA232113

NCI NIH HHS

Grant: K99 CA226342

NCI NIH HHS

Grant: P30 CA008748

NCI NIH HHS

Grant: P01 CA087497

NHLBI NIH HHS

Grant: T32 HL069768

NCI NIH HHS

Grant: P01 CA013106

NCI NIH HHS

Grant: R01 CA204228

NCI NIH HHS

Grant: K08 CA218420

NCI NIH HHS

Grant: R00 CA226342

bronzeLicense: Elsevier Non-Commercial

publisherhttp://www.cell.com/article/S1535610820302609/pdf

publisherhttps://api.elsevier.com/content/article/PII:S1535610820302609?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1535610820302609?httpAccept=text/plain

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8028848

https://doi.org/10.1016/j.ccell.2020.05.010

Fields of Study

0301 basic medicine03 medical and health sciencesAnimalsCarcinoma, Pancreatic DuctalCell Line, TumorCells, CulturedFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMice, Inbred C57BLMice, KnockoutMutationPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)RNA SplicingRNAi TherapeuticsSignal TransductionTumor Suppressor Protein p53Xenograft Model Antitumor Assays

MeSH Terms

AnimalsCarcinoma, Pancreatic DuctalCell Line, TumorCells, CulturedFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMice, Inbred C57BLMice, KnockoutMutationPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)RNA SplicingRNAi TherapeuticsSignal TransductionTumor Suppressor Protein p53Xenograft Model Antitumor Assays

Keywords

Mice, KnockoutRNA SplicingKaplan-Meier EstimateXenograft Model Antitumor AssaysGene Expression Regulation, NeoplasticMice, Inbred C57BLPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)RNAi TherapeuticsCell Line, TumorMutationAnimalsHumansFemaleTumor Suppressor Protein p53Cells, CulturedCarcinoma, Pancreatic DuctalSignal TransductionGAP17GTPase signalingKRASSF3B1hnRNPKoncogenesp53pancreatic cancersplicing inhibitors

Sustainable Development Goals

SDG 3: 3. Good health