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Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells

Cancer Cell(2024)10.1016/j.ccell.2024.08.007Source: DataRank Database

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells is a research paper published in Cancer Cell (2024). On theSindex it has a DataRank of 0. It has been cited 102 times.

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0DataRank · unranked

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Open Access102 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 18.74)OA: greenTopics (50)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
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Reusable (0/3)

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Authors (38)

Paulina Coutifaris,David Brocks ORCID,Guanning Wang ORCID,Tarek Azar,Sabrina Solis ORCID

Live enrichment

PubMed:39214097 OpenAlex:https://openalex.org/W4401996447

National Institutes of Health

Grant: P50 CA174523

National Institutes of Health

Grant: RO1CA258113

National Institutes of Health

Grant: R01CA244936

National Institutes of Health

Grant: P50CA261608

National Institutes of Health

Grant: P30CA016520

National Institutes of Health

Grant: P50CA225450

National Institutes of Health

Grant: K08 CA230157

National Institutes of Health

Grant: P30CA016087

National Institutes of Health

Grant: R01 CA273018

NCI NIH HHS

Grant: R01 CA258113

FWCI

18.74

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

greenLicense: http://www.elsevier.com/open-access/userlicense/1.0/

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11387127/

publisherhttps://api.elsevier.com/content/article/PII:S1535610824003064?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S1535610824003064?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.ccell.2024.08.007

Fields of Study

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune Cell Function and InteractionHumansCD8-Positive T-LymphocytesProgrammed Cell Death 1 ReceptorMelanomaImmune Checkpoint InhibitorsCTLA-4 AntigenAntineoplastic Combined Chemotherapy ProtocolsReceptors, Antigen, T-CellFemaleSingle-Cell AnalysisMale

MeSH Terms

Immune Checkpoint InhibitorsAntineoplastic Combined Chemotherapy ProtocolsFemaleHumansMaleMelanomaReceptors, Antigen, T-CellCD8-Positive T-LymphocytesSingle-Cell AnalysisCTLA-4 AntigenProgrammed Cell Death 1 Receptor

Keywords

Cytotoxic T cellProgenitor cellImmunologyCD8ProgenitorBiologyClonal deletionCancer researchCell biologyImmune systemT cellStem cellGeneticsIn vitroT-cell receptorCTLA-4 blockadeCheckpoint blockadePD-1 blockadeT cell exhaustionclonotypic analysiscombination checkpoint blockadeimmunotherapymelanomaprogenitor exhausted CD8(+) T cellssingle-cell sequencing

Sustainable Development Goals

SDG 0: Zero hunger

Cyclone Algorithm for Tracking Clonal Trajectories Across Time

10.5281/zenodo.12754870Zenodo

Cyclone Algorithm for Tracking Clonal Trajectories Across Time

10.5281/zenodo.12754871Zenodo