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A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model

Cell(2020)10.1016/j.cell.2020.09.049Source: DataRank Database

A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model is a research paper published in Cell (2020). On theSindex it has a DataRank of 0. It has been cited 388 times.

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Open Access388 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (11 grants)Impact (FWCI 8.01)OA: hybridTopics (133)Linked Datasets (14)DataCite Reuse (14)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

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Context only (not used in score)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (44)

S. Momsen Reincke ORCID,Hans‐Christian Kornau ORCID,Elisa Sánchez-Sendin ORCID,Victor M. Corman ORCID,Hejun Liu

Live enrichment

PubMed:33058755 PMC:PMC7510528 OpenAlex:https://openalex.org/W3087410177

NIAID NIH HHS

Grant: K99 AI139445

NIGMS NIH HHS

Grant: P41 GM103393

National Institutes of Health

Grant: 5K99AI139445-02

Mechanistic understanding of influenza-host interactions from a zoonotic perspective

National Institutes of Health

Grant: 8P41GM103393-33

A Synchroton Radiation Structural Biology Resource

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

Helmholtz-Gemeinschaft

U.S. Department of Energy

Bill and Melinda Gates Foundation

National Institutes of Health

Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie

Deutsche Forschungsgemeinschaft

FWCI

8.01

Citation Percentile

1.0%

Citation Trend

2014

2020

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.cell.com/article/S0092867420312460/pdf

publisherhttp://www.cell.com/article/S0092867420312460/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0092867420312460?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0092867420312460?httpAccept=text/plain

journalhttps://doi.org/10.1016/j.cell.2020.09.049

Fields of Study

SARS-CoV-2 and COVID-19 ResearchMonoclonal and Polyclonal Antibodies ResearchCOVID-19 Clinical Research Studies0301 basic medicine03 medical and health sciencesAngiotensin-Converting Enzyme 2AnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralAntigen-Antibody ReactionsBetacoronavirusBinding SitesCOVID-19Coronavirus InfectionsCricetinaeCrystallography, X-RayDisease Models, AnimalHumansKineticsLungMiceMice, Inbred C57BLMolecular Dynamics SimulationPandemicsPeptidyl-Dipeptidase APneumonia, ViralProtein BindingSARS-CoV-2Spike Glycoprotein, Coronavirus

MeSH Terms

BetacoronavirusAngiotensin-Converting Enzyme 2COVID-19SARS-CoV-2AnimalsAntibodies, MonoclonalAntibodies, ViralAntigen-Antibody ReactionsBinding SitesDisease Models, AnimalCricetinaeHumansKineticsPeptidyl-Dipeptidase ALungMice, Inbred C57BLPneumonia, ViralProtein BindingCoronavirus InfectionsCrystallography, X-RayMiceMolecular Dynamics SimulationAntibodies, NeutralizingPandemicsSpike Glycoprotein, Coronavirus

Keywords

Monoclonal antibodyVirologyBiologyCoronavirus disease 2019 (COVID-19)AntibodyPandemicCoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)EpitopeImmunologyHamster2019-20 coronavirus outbreakNeutralizing antibodyVirusDiseaseInfectious disease (medical specialty)PathologyMedicineMolecular biologyOutbreakCrystal StructuresHamster ModelAutoreactivitySelf-antigensPost-exposureSelf-reactivityCovid-19Sars-cov-2Antibodies, Monoclonal: therapeutic useAce2 protein, mouseAntibodies, ViralCrystallography, X-RaySpike Glycoprotein, Coronavirus: chemistryAntigen-Antibody ReactionsBetacoronavirus: metabolismMiceSpike Glycoprotein, Coronavirus: immunologyPeptidyl-Dipeptidase A: metabolismCricetinaePneumonia, Viral: virologyCoronavirus Infections: drug therapyLunginfo:eu-repo/classification/ddc/610Coronavirus Infections: virologySpike Glycoprotein, Coronavirus: metabolismAntibodies, Monoclonalspike protein, SARS-CoV-2Pneumonia, Viral: drug therapySpike Glycoprotein, CoronavirusAngiotensin-Converting Enzyme 2Lung: pathologyFunction and Dysfunction of the Nervous SystemCoronavirus InfectionsProtein BindingAntibodies, Viral: immunologyPeptidyl-Dipeptidase A: chemistryCoronavirus Infections: pathologyACE2 protein, humanPeptidyl-Dipeptidase AMolecular Dynamics SimulationArticleAntibodies, Monoclonal: immunologyBetacoronavirusPneumonia, Viral: pathologyAnimalsHumansPandemicsBinding SitesBetacoronavirus: immunologyLung: metabolismAntibodies, NeutralizingMice, Inbred C57BLDisease Models, AnimalKineticsAntibodies, Viral: therapeutic useLung: immunologyAntibodies, Neutralizing: immunologyBetacoronavirus: pathogenicity

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment

10.6084/m9.figshare.14471586.v1figshare

Additional file 1 of Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment

10.6084/m9.figshare.14471586figshare

Additional file 1 of Impact of the N501Y substitution of SARS-CoV-2 Spike on neutralizing monoclonal antibodies targeting diverse epitopes

10.6084/m9.figshare.14509551.v1figshare

Additional file 1 of Impact of the N501Y substitution of SARS-CoV-2 Spike on neutralizing monoclonal antibodies targeting diverse epitopes

10.6084/m9.figshare.14509551figshare

Additional file 1 of Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

10.6084/m9.figshare.16815699.v1figshare

Additional file 1 of Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

10.6084/m9.figshare.16815699figshare

Additional file 1 of Application of Baculovirus Expression Vector system (BEV) for COVID-19 diagnostics and therapeutics: a review

10.6084/m9.figshare.20252899.v1figshare

Additional file 1 of Application of Baculovirus Expression Vector system (BEV) for COVID-19 diagnostics and therapeutics: a review

10.6084/m9.figshare.20252899figshare

Additional file 4 of Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

10.6084/m9.figshare.16815708.v1figshare

Additional file 3 of Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

10.6084/m9.figshare.16815705figshare

Additional file 2 of Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

10.6084/m9.figshare.16815702figshare

Additional file 2 of Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

10.6084/m9.figshare.16815702.v1figshare

Additional file 4 of Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

10.6084/m9.figshare.16815708figshare

Additional file 3 of Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

10.6084/m9.figshare.16815705.v1figshare

A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model

FAIR Checklist

Authors (44)

Funding (11 grants)

Impact

Open Access

Topics

Linked Datasets (14)

Annotations (Europe PMC)